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TranscriptomicsTranscription profiling of mouse P18, P24, P46, P104, and P46DR (dark reared) non-deprived vs. deprived visual cortex (GEO Super Series)
This SuperSeries is composed of the following subset Series:; GSE4263: P18 mouse non-deprived vs. deprived visual cortex; GSE4264: P24 mouse non-deprived vs. deprived visual cortex; GSE4265: P46 mouse non-deprived vs. deprived visual cortex; GSE4266: P104 mouse non-deprived vs. deprived visual corte...
ORGANISM(S): Mus musculus 
2008-06-13 | E-GEOD-4269 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse P104 non-deprived vs. deprived visual cortex
Wild-type (C57Bl6) mice underwent monocular enucleation at P100 and were sacrificed 4 days later at P104. Bilateral (non-deprived and deprived) visual cortex was dissected from 1-mm thick coronal sections, and total RNA was extracted from the tissue lysate using Trizol (Gibco-BRL). Experiment Overal...
ORGANISM(S): Mus musculus 
2008-06-13 | E-GEOD-4266 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse visual cortex from P46 mouse non-deprived vs. deprived
Wild-type (C57Bl6) mice underwent monocular enucleation at P42 and were sacrificed 4 days later at P46. Bilateral (non-deprived and deprived) visual cortex was dissected from 1-mm thick coronal sections, and total RNA was extracted from the tissue lysate using Trizol (Gibco-BRL). Experiment Overall ...
ORGANISM(S): Mus musculus 
2008-06-13 | E-GEOD-4265 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse P24 animals non-deprived vs. deprived visual cortex
Wild-type (C57Bl6) mice underwent monocular enucleation at P20 and were sacrificed 4 days later at P24. Bilateral (non-deprived and deprived) visual cortex was dissected from 1-mm thick coronal sections, and total RNA was extracted from the tissue lysate using Trizol (Gibco-BRL). Experiment Overall ...
ORGANISM(S): Mus musculus 
2008-06-13 | E-GEOD-4264 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouseP46DR dark reared mouse non-deprived vs. deprived visual cortex
Wild-type (C57Bl6) mice were dark reared from birth to P42, then underwent monocular enucleation at P42. They were then placed in a normal light-dark environment for 4 days, after which they were sacrificed (at P46). Visual cortex was dissected from 1-mm thick coronal sections, and total RNA was ext...
ORGANISM(S): Mus musculus 
2008-06-13 | E-GEOD-4267 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse visual cortex from wild type animals sacrificed at P18 after mononuclear enucleation
Wild-type (C57Bl6) mice underwent monocular enucleation at P14 and were sacrificed 4 days later at P18. Bilateral (non-deprived and deprived) visual cortex was dissected from 1-mm thick coronal sections, and total RNA was extracted from the tissue lysate using Trizol (Gibco-BRL). Experiment Overall ...
ORGANISM(S): Mus musculus 
2008-06-13 | E-GEOD-4263 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse primary visual cortext from animals treated with monocular deprivation (MD), dark rearing and controls reveals binding protein of Insulin-like Growth Factor 1 is highly upregulated after MD
Two key paradigms for examining activity-dependent development of primary visual cortex (V1) involve either reduction of activity in both eyes via dark-rearing (DR) or imbalance of activity between the two eyes via monocular deprivation (MD).,Combining DNA microarray analysis with computational appr...
ORGANISM(S): Mus musculus 
2007-07-07 | E-GEOD-4537 | biostudies-arrayexpress
TranscriptomicsChanges in miRNA expression in mouse primary visual cortex following visual deprivation
Visual deprivation, either in the form of dark rearing (DR) or monocular deprivation (MD) are established paradigms for studying cortical plasticity. We have used miRNA microarray to uncover miRNAs whose expression is altered in primary visual cortex following DR and/or MD. C57BL6 mice were reared...
ORGANISM(S): Mus musculus 
2011-09-03 | E-GEOD-31536 | biostudies-arrayexpress
TranscriptomicsLayer 4 Visual Cortex Star Pyramid Monocular Deprivation Microarray Study
Microarray expression profiling of manually sorted m-citirin-labeled layer 4 visual cortex star pyramid neurons from deprived and non-deprived hemispheres. Monocular deprivation by TTX-injection (at P12-13 and again at P13-14), followed by manual sorting of m-Citrin-labeled Layer 4 Visual Cortex Sta...
ORGANISM(S): Mus musculus 
2014-04-12 | E-GEOD-56758 | biostudies-arrayexpress
TranscriptomicsGenome-wide activity-dependent MeCP2 phosphorylation regulates nervous system development and function [visual cortex]
Autism spectrum disorders such as Rett syndrome (RTT) have been hypothesized to arise from defects in experience-dependent synapse maturation. RTT is caused by mutations in MECP2, a nuclear protein that becomes phosphorylated at S421 in response to neuronal activation. We show here that disruption o...
ORGANISM(S): Mus musculus 
2011-09-07 | E-GEOD-31850 | biostudies-arrayexpress
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