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TranscriptomicsDifferential expression in Wn5a and vector transduced 4T1 cells. [RNA-Seq]
A highly metastatic breast cancer cell line, 4T1, was used to generate stable Wnt5a expressing and vector only control cells. Cells were generated using lentivirus infection and selection with blasticidin. Expression of Wnt5a was confirmed using western blot. Cell behaviour was characterized. Wnt5...
ORGANISM(S): Mus musculus 
2013-06-26 | E-GEOD-41792 | biostudies-arrayexpress
TranscriptomicsWnt5A promotes an adaptive, senescent-like stress response, while continuing to drive invasion in melanoma cells.
We have previously shown that Wnt5A drives invasion in melanoma. We have also shown that Wnt5A promotes resistance to therapy designed to target the BRAF(V600E) mutation in melanoma. Here, we show that melanomas characterized by high levels of Wnt5A respond to therapeutic stress by increasing p21 an...
ORGANISM(S): Homo sapiens 
2015-08-07 | E-GEOD-50004 | biostudies-arrayexpress
TranscriptomicsDifferential expression in Wn5a and vector transduced 4T1 cells. [Affymetrix microarray data]
A highly metastatic breast cancer cell line, 4T1, was used to generate stable Wnt5a expressing and vector only control cells. Cells were generated using lentivirus infection and selection with blasticidin. Expression of Wnt5a was confirmed using western blot. Cell behaviour was characterized. Wnt5...
ORGANISM(S): Mus musculus 
2013-06-26 | E-GEOD-41791 | biostudies-arrayexpress
TranscriptomicsSWI/SNF Chromatin-Remodeling Factor Smarcd3/Baf60c Controls Epithelial-Mesenchymal Transition by Inducing Wnt5a Signaling
We previously identified a gene signature predicted to regulate the epithelial-mesenchymal transition (EMT) in both epithelial tissue stem cells and breast cancer cells. A phenotypic RNA interference (RNAi) screen identified the genes within this 140-gene signature that promoted the conversion of me...
ORGANISM(S): Homo sapiens 
2013-08-19 | E-GEOD-40145 | biostudies-arrayexpress
ProteomicsWNT5A is transported via lipoprotein particles in the cerebrospinal fluid to regulate hindbrain morphogenesis
WNTs are hydrophobic, lipid-modified proteins that control multiple functions in development and disease via short- and long-range signaling. However, it is unclear how these hydrophobic molecules reach over long distances in the mammalian brain. Here we show that WNT5A is produced by the choroid pl...
ORGANISM(S): Rattus norvegicus (Rat) 
2019-01-14 | PXD011918 | Pride
Co-immunoprecipitation Wnt5a Lc-ms/ms 
TranscriptomicsWnt5a-deficient vs. wild-type E18 liver
Transcriptional profiling of E18.5 livers derived from Wnt5a-deficient (KO) mice compared to those from littermate wild-type (WT) mice. RNA samples were extracted from whole livers derived from E18.5 fetuses. Two-condition experiment: Wnt5a KO vs. WT whole livers. Total RNA samples were extracted fr...
ORGANISM(S): Mus musculus 
2013-02-07 | E-GEOD-41803 | biostudies-arrayexpress
GenomicsHIF2 regulates intestinal Wnt5a expression
HIF2 regulates intestinal Wnt5a expression
PRJNA776829 | ENA
TranscriptomicsWnt5A Enhances Resistance of Melanoma Cells to Targeted BRAF Inhibitors
About half of all melanomas harbor a constitutively active mutant BRAFV600E/K kinase that can be selectively inhibited by targeted BRAF inhibitors (BRAFi). While patients treated with BRAFi initially exhibit measurable clinical improvement, the majority of patients eventually develop drug resistance...
ORGANISM(S): Homo sapiens 
2014-03-06 | E-GEOD-55583 | biostudies-arrayexpress
TranscriptomicsDifferential expression in Wn5a and vector transduced 4T1 cells.
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2013-06-26 | E-GEOD-41793 | biostudies-arrayexpress
TranscriptomicsTreatment of CHRF288-11 Megakaryocytic Cells with Wnt compounds
CHRF288-11 cells were treated with Wnt3a (150ng/ml) and/ot Wnt5a (1200ng/ml) and RNA was harvested after 8 hours of treatment Gene expression was analysed using Human WG6 V3 Illumina Beadarrays There are four experimental groups (Wnt3a Treated, Wnt5a Treated, Wnt3a + Wnt5a treated and Untreated (con...
ORGANISM(S): Homo sapiens 
2012-11-07 | E-GEOD-42071 | biostudies-arrayexpress
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