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GenomicsModeling the ESR1 tyrosine 537 mutation with CRISPR-Cas9 for mechanistic studies and evaluation of therapeutic approaches for metastatic breast cancer [ChIP-Seq]
Estrogen receptor-α (ERα) is an important driver of breast cancer and is the target for hormonal therapies, anti-estrogens and drugs that limit estrogen biosynthesis (aromatase inhibitors). Mutations in the ESR1 gene identified in metastatic breast cancer provide a potential mechanism for acquired...
ORGANISM(S): Homo sapiens 
2016-10-25 | E-GEOD-78284 | biostudies-arrayexpress
TranscriptomicsModeling the ESR1 tyrosine 537 mutation with CRISPR-Cas9 for mechanistic studies and evaluation of therapeutic approaches for metastatic breast cancer [RNA-Seq]
Estrogen receptor-α (ERα) is an important driver of breast cancer and is the target for hormonal therapies, anti-estrogens and drugs that limit estrogen biosynthesis (aromatase inhibitors). Mutations in the ESR1 gene identified in metastatic breast cancer provide a potential mechanism for acquired...
ORGANISM(S): Homo sapiens 
2016-10-25 | E-GEOD-78285 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of estrogen receptor mutants, S463P, Y537S and D538G in MCF7 cells
Analysis of MCF7 cells transfected with ER mutants (S463P, Y537S and D538G) in phenol-red free, charcoal stripped FBS media and regular DMEM/F12 media. Results provide insight on the gene expression profiles induced by the various ER mutants. Total RNA extracted from transfected cells 48 hours after...
ORGANISM(S): Homo sapiens 
2013-10-25 | E-GEOD-51448 | biostudies-arrayexpress
GenomicsEffect of diptoindonesin G on T47D cells overexpressing the Y537S ER mutation
Effect of diptoindonesin G on T47D cells overexpressing the Y537S ER mutation
PRJNA847231 | ENA
GenomicsH3K27Ac in MCF7 Y537S ER mutant cells and RNAseq with and without treatment with THZ1
H3K27Ac in MCF7 Y537S ER mutant cells and RNAseq with and without treatment with THZ1
PRJNA417235 | ENA
TranscriptomicsH3K27Ac in MCF7 Y537S ER mutant cells and RNAseq with and without treatment with THZ1
H3K27Ac ChIP-seq in MCF7 Y537S ER mutant cells RNAseq analysis of MCF7 Y537S ER mutant cells treated with veh and THZ1
ORGANISM(S): Homo sapiens 
2018-02-15 | GSE106552 | GEO
TranscriptomicsEffect of diptoindonesin G on T47D cells overexpressing the Y537S ER mutation
To investigate the effect of diptoindonesin G on breast cancer cells expressing the estrogen receptor Y537S ligand binding domain mutation, we treated T47D cells overexpressing the ER Y537S mutation and treated them with vehicle or diptoindonesin G and performed differential gene expression analysis...
ORGANISM(S): Homo sapiens 
2022-06-11 | GSE205716 | GEO
GenomicsIdentification and validation of an ESR1 Y537S mutant-specific enhancer and its downstream target IGFBP3
Identification and validation of an ESR1 Y537S mutant-specific enhancer and its downstream target IGFBP3
PRJNA1470525 | ENA
UnknownERα/PR crosstalk is altered in the context of the ERα Y537S mutation and contributes to endocrine therapy-resistant tumor proliferation.
Not available
S-EPMC10689488 | biostudies-literature
GenomicsESR1 Y537S and D538G mutations drive resistance to CDK4/6 inhibitors in estrogen receptor-positive breast cancer
ESR1 Y537S and D538G mutations drive resistance to CDK4/6 inhibitors in estrogen receptor-positive breast cancer
PRJNA1183347 | ENA
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