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ProteomicsYEATS2 O-GlcNAcylation Promotes Chromatin Association of the ATAC complex and Lung Cancer Tumorigenesis
The intracellular O-linked N-acetylglucosamine (O-GlcNAc) modification is known to be enriched in the nucleus and in particular on chromatin, but many of its chromatin targets remain to be identified. Herein we demonstrate the O-GlcNAcylation of YEATS Domain Containing 2 (YEATS2), a subunit of the c...
ORGANISM(S): Homo sapiens (Human) 
2025-07-28 | PXD060970 | Pride
O-glcnac  yeats2  atac  h3k9ac  zzz3 
UnknownThe value of acetylation reader YEATS2 in hepatocellular carcinoma management.
Not available
S-EPMC12307690 | biostudies-literature
GenomicsDopaminergic neurons are vulnerable to dysregulation of YEATS2-dependent calcium homeostasis
Dopaminergic neurons are vulnerable to dysregulation of YEATS2-dependent calcium homeostasis
PRJNA1314219 | ENA
UnknownYEATS2 promotes malignant phenotypes of esophageal squamous cell carcinoma via H3K27ac activated-IL6ST.
Not available
S-EPMC11876388 | biostudies-literature
UnknownYEATS2 links histone acetylation to tumorigenesis of non-small cell lung cancer.
Not available
S-EPMC5651844 | biostudies-literature
UnknownYEATS2 O-GlcNAcylation promotes chromatin association of the ATAC complex and lung cancer tumorigenesis.
Not available
S-EPMC12275198 | biostudies-literature
GenomicsMaintenance of histone crotonylation by YEATS2 and GCDH drives EMT in head and neck cancer [ChIP-seq]
Maintenance of histone crotonylation by YEATS2 and GCDH drives EMT in head and neck cancer [ChIP-seq]
PRJNA1154002 | ENA
UnknownOverexpression of YEATS2 Remodels the Extracellular Matrix to Promote Hepatocellular Carcinoma Progression via the PI3K/AKT Pathway.
Not available
S-EPMC10046954 | biostudies-literature
GenomicsMaintenance of histone crotonylation by YEATS2 and GCDH drives EMT in head and neck cancer [RNA-seq]
Maintenance of histone crotonylation by YEATS2 and GCDH drives EMT in head and neck cancer [RNA-seq]
PRJNA1154005 | ENA
TranscriptomicsDopaminergic neurons are vulnerable to dysregulation of YEATS2-dependent calcium homeostasis
YEATS2, a chromatin-associated factor, is essential for maintaining dopaminergic (DA) synaptic integrity, but the underlying mechanism remains unclear. Using Drosophila, we show that neuronal depletion of YEATS2 alters brain transcriptomes, downregulating metabolic genes and upregulating G protein–c...
ORGANISM(S): Drosophila melanogaster 
2026-04-11 | GSE307078 | GEO
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