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ProteomicsAutophagosome Proteomics of HEK293 cells
Pan-caspase inhibitor Z-VAD-fmk acts as an inhibitor of peptide:N-glycanase (NGLY1); an endoglycosidase which cleaves N-linked glycans from glycoproteins exported from the endoplasmic reticulum during ER-associated degradation (ERAD). Pharmacological N-glycanase inhibition by Z-VAD-fmk or siRNA knoc...
ORGANISM(S): Homo sapiens (Human) 
2022-01-12 | PXD020367 | Pride
Autophagy  autophagosome  ngly1  n-glycanase  z-vad-fmk  off-target 
UnknownOff-target inhibition of NGLY1 by the polycaspase inhibitor Z-VAD-fmk induces cellular autophagy.
Not available
S-EPMC9304259 | biostudies-literature
UnknownEvaluation of Z-VAD-FMK as an anti-apoptotic drug to prevent granulosa cell apoptosis and follicular death after human ovarian tissue transplantation.
Not available
S-EPMC6420548 | biostudies-literature
TranscriptomicsTranscription profiling of chicken histone H1 null mutant cells
In chicken DT40 cells, there are six linker histone H1 variants and 12 of coding genes. We have previously reported of 11 out of 12 H1 knock out DT40 cells (Takami et al., Genes to Cell 1997 [PMID:9491804]) but complete H1 null DT40 cells could not established, so far. We identified one of the H1 va...
ORGANISM(S): Gallus gallus 
2008-11-04 | E-GEOD-8483 | biostudies-arrayexpress
UnknownPlasmodium falciparum metacaspase PfMCA-1 triggers a z-VAD-fmk inhibitable protease to promote cell death.
Not available
S-EPMC3157471 | biostudies-literature
UnknownThe Caspase Inhibitor Z-VAD-FMK Alleviates Endotoxic Shock via Inducing Macrophages Necroptosis and Promoting MDSCs-Mediated Inhibition of Macrophages Activation.
Not available
S-EPMC6687755 | biostudies-literature
UnknownPan-caspase inhibitor protects against noise-induced hearing loss in a rodent model.
Not available
S-EPMC11847858 | biostudies-literature
TranscriptomicsRNA-Seq based analysis of chondroblasts subjected to general caspase inhibition revealed modulation of a spectrum of osteoarthritis related genes
Objective: The knowledge about functions of caspases, traditionally associated with cell death and inflammation, keeps expanding also regarding cartilage. Active caspases are expressed by chondrocytes within the growth plate and caspase inhibition in limb-derived chondroblasts altered osteogenesis-r...
ORGANISM(S): Mus musculus 
2021-08-24 | GSE164835 | GEO
TranscriptomicsRNA-Seq Analyses of the apoptosis and necroptosis in MEF
Purpose: we used next generation sequencing to analyze gene expression profiles of MEF treated with PBS (control), TNF-ɑ + Cycloheximide (TC) or TNF-ɑ + Cycloheximide+ z-VAD-fmk (TCZ). The goals of this study are to compare the different gene expression profiles between MEF treated with TC compared ...
ORGANISM(S): Mus musculus 
2020-01-09 | GSE143294 | GEO
UnknownGPR83 protects cochlear hair cells against ibrutinib-induced hearing loss through AKT signaling pathways.
Not available
S-EPMC12003303 | biostudies-literature
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