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ProteomicsZHX3 interacts with CEBPB to repress hepatic gluconeogenic gene expression and uric acid secretion
ZHX3, which encodes for a transcriptional repressor, is associated with fasting blood glucose (FBG) levels and increased type 2 diabetes (T2D) risk but its role in cell types involved in glucose metabolism is not well understood. Here, we show that the deletion of ZHX3 in the human pancreatic β cell...
ORGANISM(S): Homo sapiens (Human) 
2026-04-27 | PXD046714 | Pride
Beta cell Type 2 diabetes  zhx3  gluconeogenesis  fasting blood glucose  hepatic glucose production  liver  hepatocytes  uric acid  slc17a1 
GenomicsGenome-wide distribution of ZHX3 in human fibroblast cells.
Genome-wide distribution of ZHX3 in human fibroblast cells.
PRJNA767336 | ENA
GenomicsTranscriptomic analysis of ZHX3-depleted HepG2 cells
Transcriptomic analysis of ZHX3-depleted HepG2 cells
PRJNA798264 | ENA
GenomicsGenome-wide distribution of ZHX3 in human fibroblast cells.
ChIP-seq analysis of ZHX3 in IMR-90 cells. We found that ZHX3 is enriched at the promoter site of target genes.
ORGANISM(S): Homo sapiens 
2022-01-01 | GSE184992 | GEO
GenomicsEffect of deletion of ZHX3 on gene expression in human pancreatic beta cells EndoC-BH1
Effect of deletion of ZHX3 on gene expression in human pancreatic beta cells EndoC-BH1
PRJNA989040 | ENA
TranscriptomicsEffect of deletion of ZHX3 on gene expression in human pancreatic beta cells EndoC-BH1
ZHX3 is a transcriptional factor whose role in human pancreatic beta cells is not well understood. In attempt to identify the genes that ZHX3 regulates in beta cells, we KO ZHX3 using CRISPR in EndoC-βH1 cells and performed RNA-Seq. We have only identified 36 and 31 genes that were significantly up ...
ORGANISM(S): Homo sapiens 
2025-02-26 | GSE236102 | GEO
UnknownLoss of the transcription repressor ZHX3 induces senescence-associated gene expression and mitochondrial-nucleolar activation.
Not available
S-EPMC8794122 | biostudies-literature
TranscriptomicsTranscriptomic analysis of ZHX3-depleted HepG2 cells
The aim of this RNA-Seq analysis was to identify target genes of the transcription repressor ZHX3 in HepG2 cells. To do so, four stable lines were generated in HepG2 using three different ZHX3-targeting CRISPR constructs and an empty vector construct. Bulk RNA-Seq analysis was performed on these fou...
ORGANISM(S): Homo sapiens 
2025-02-26 | GSE193872 | GEO
UnknownZHX3 promotes the progression of urothelial carcinoma of the bladder via repressing of RGS2 and is a novel substrate of TRIM21.
Not available
S-EPMC8088937 | biostudies-literature
OtherlncRNA-operated stem cell fate control: RPS3 organizes the in situ Gm16751-Zhx3 interactome to program spermatogonial differentiation [RIC-Seq]
Long non-coding RNAs (lncRNAs) play pivotal regulatory roles in mammalian male gametogenesis. Advances in high-throughput technologies have demonstrated that lncRNAs orchestrate robust, flexible, and context-specific gene regulatory networks through dynamic interactions with proteins, DNA, and RNA, ...
ORGANISM(S): Mus musculus 
2026-06-10 | GSE296666 | GEO
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