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ProteomicsValidation of a novel shotgun proteomic workflow for the discovery of protein-protein interactions: focus on ZNF521
The study of protein-protein interactions is increasingly relying on mass spectrometry (MS). The classical approach of separating immunoprecipitated proteins by SDS-PAGE followed by in-gel digestion is long and labour-intensive. Besides, it is difficult to integrate it with most quantitative MS-base...
ORGANISM(S): Homo sapiens (Human) 
2015-04-07 | PXD001609 | Pride
Ap-ms  interactomics  18o labelling  znf521  znf423  spt16  spt5  nurd core complex  proteomics  mass spectrometry  shotgun proteomics 
ProteomicsValidation of a novel shotgun proteomic workflow for the discovery of protein-protein interactions: focus on ZNF521
The study of protein-protein interactions is increasingly relying on mass spectrometry (MS). The classical approach of separating immunoprecipitated proteins by SDS-PAGE followed by in-gel digestion is long and labour-intensive. Besides, it is difficult to integrate it with most quantitative MS-base...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080723 | MassIVE
UnknownZNF521 sustains the differentiation block in MLL-rearranged acute myeloid leukemia.
Not available
S-EPMC5432245 | biostudies-literature
GenomicsZNF521 enhances MLL-AF9-dependent hematopoietic stem cell transformation in acute myeloid leukemias by altering the gene expression landscape
ZNF521 enhances MLL-AF9-dependent hematopoietic stem cell transformation in acute myeloid leukemias by altering the gene expression landscape
PRJNA750400 | ENA
TranscriptomicsZNF521 enhances MLL-AF9-dependent hematopoietic stem cell transformation in acute myeloid leukemias by altering the gene expression landscape
Leukemias derived from the MLL-AF9 rearrangement rely on deranged transcriptional networks. ZNF521, a transcription co-factor implicated in the control of hematopoiesis, has been proposed to sustain leukemic transformation in collaboration with other oncogenes. We demonstrate here that ZNF521 mRNA l...
ORGANISM(S): Homo sapiens 
2022-03-24 | GSE181006 | GEO
UnknownZNF521 which is downregulated by miR-802 suppresses malignant progression of Hepatocellular Carcinoma through regulating Runx2 expression.
Not available
S-EPMC7477442 | biostudies-literature
TranscriptomicsThe stem cell-associated transcription co-factor, ZNF521, interacts with GLI1 and GLI2 and enhances the activity of the Sonic hedgehog pathway
ZNF521 is a transcription co-factor with recognized regulatory functions in haematopoietic, osteo-adipogenic and neural progenitor cells. Among its diverse activities, ZNF521 has been implicated in the regulation of medulloblastoma (MB) cells, where the Hedgehog (HH) pathway, has a key role in the d...
ORGANISM(S): Homo sapiens 
2020-10-03 | GSE158925 | GEO
UnknownZNF521 Is Correlated with Tumor Immune Cell Infiltration and Act as a Valuable Prognostic Biomarker in Gastric Cancer.
Not available
S-EPMC9606838 | biostudies-literature
GenomicsThe stem cell-associated transcription co-factor, ZNF521, interacts with GLI1 and GLI2 and enhances the activity of the Sonic hedgehog pathway
The stem cell-associated transcription co-factor, ZNF521, interacts with GLI1 and GLI2 and enhances the activity of the Sonic hedgehog pathway
PRJNA667032 | ENA
UnknownZNF521 Enhances MLL-AF9-Dependent Hematopoietic Stem Cell Transformation in Acute Myeloid Leukemias by Altering the Gene Expression Landscape.
Not available
S-EPMC8509509 | biostudies-literature
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