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Proteomics15-141 The endoplasmic reticulum-associated mRNA-binding protein ERBP1
Kinetoplastids rely heavily on post-transcriptional mechanisms for control of gene expression, and on RNA-binding proteins that regulate mRNA splicing, translation and decay. Trypanosoma brucei ERBP1 (Tb927.10.14150) and ERBP2 (Tb927.9.9550) were previously identified as mRNA binding proteins that l...
ORGANISM(S): Trypanosoma brucei 
2020-01-16 | PXD016106 | Pride
15-141 rna-binding proteins  trypanosoma brucei  post-transcripcional control 
TranscriptomicsPervasive TTP binding but selective target mRNA destabilization in the macrophage transcriptome [PAR-iCLIP]
Precise control of mRNA decay is fundamental for robust yet not exaggerated inflammatory responses to pathogens. Parameters determining the specificity and extent of mRNA degradation within the entire inflammation-associated transcriptome remain incompletely understood. Using transcriptome-wide high...
ORGANISM(S): Mus musculus 
2016-05-17 | E-GEOD-63466 | biostudies-arrayexpress
TranscriptomicsIdentification of mRNAs bound and regulated by human LIN28 proteins and molecular requirements for RNA recognition
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2013-02-26 | E-GEOD-44616 | biostudies-arrayexpress
TranscriptomicsTTP binding site atlas in the macrophage transcriptome reveals a switch for inflammation resolution
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2016-05-17 | E-GEOD-63468 | biostudies-arrayexpress
TranscriptomicsNutrient-Regulated Antisense and Intragenic RNAs Modulate a Signal Transduction Pathway
The budding yeast Saccharomyces cerevisiae alters its gene expression profile in response to a change in nutrient availability. The PHO-system is a well-studied case in the transcriptional regulation responding to nutritional changes in which a set of genes (PHO genes) is expressed to activate phosp...
ORGANISM(S): Saccharomyces cerevisiae 
2008-12-23 | E-GEOD-13350 | biostudies-arrayexpress
TranscriptomicsDistribution of different proteins related to sister chromatid cohesion during the cell cycle.
This series is a supplementary data set for the manuscript titled "Cohesin relocation from sites of chromosomal loading to places of convergent transcription" All data shown in the paper were registered (30 ChIP-chip and one transcription data). Experimental design: 1. Type of experiment: a. ChIP ...
ORGANISM(S): Saccharomyces cerevisiae 
2010-06-09 | E-GEOD-1461 | biostudies-arrayexpress
GenomicsChIPseq measurement of transcriptional engagement and replication stress at the Drosophila Mid-blastula Transition
These experiments measure genome-wide RNA Pol II binding in precisely staged wild-type embryos at five time points spanning the maternal to zygotic transition (nuclear cycles 12 through 14) of Drosophila melanogaster. In addition, RNA Pol II binding at nuclear cycle 13 is measured in embryos mutant ...
ORGANISM(S): Drosophila melanogaster 
2015-03-05 | E-GEOD-62925 | biostudies-arrayexpress
TranscriptomicsGene expression over the course of xylem tracheary element formation in cell suspension cultures of Arabidopsis thaliana
Transcriptomic analysis of gene expression during the differentiation of cell suspension cultures into tracheary elements using the biological system published by Pesquet et al., Current Biology (2010): tracheary element differentiation was triggered by externally supplying hormone-free habituated c...
ORGANISM(S): Arabidopsis thaliana 
2015-09-18 | E-GEOD-73146 | biostudies-arrayexpress
TranscriptomicsReplication and Protein binding profile of chromosome VI of S.cerevisiae
Type of experiment: ChIP-chip (Chromatin immunoprecipitation on DNA chip) analyses of replication related, checkpoint related proteins and BrdU incorporated regions at 300bp resolution. Newly developed S.cerevisiae chromosome VI tiling array produced by affymetrix was used. Experimental factors:Dis...
ORGANISM(S): Saccharomyces cerevisiae 
2010-06-05 | E-GEOD-486 | biostudies-arrayexpress
TranscriptomicsTop1 and Top2-mediated replication fork integrity
DNA topoisomerases solve topological problems during chromosome metabolism. We investigated where and when Top1 and Top2 are recruited on replicating chromosomes and how their inactivation affects fork integrity and DNA damage checkpoint activation. We show that, in the context of replicating chroma...
ORGANISM(S): Saccharomyces cerevisiae 
2010-06-05 | E-GEOD-8305 | biostudies-arrayexpress
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