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ProteomicsHigh-Throughput Label-free Single-Cell Proteomics Enabled by Multicolumn NanoLC with a 5-min Cycle Time
Mass spectrometry (MS)-based single-cell proteomics (SCP) enables proteome-wide analysis at single-cell resolution, offering insights into cellular heterogeneity, biological processes, and disease mechanisms. However, conventional nanoLC-MS workflows are constrained by long gradients and low through...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2026-05-21 | PXD070201 | Pride
5-min cycle time 288 spd High-throughput scp Nanolc-ms/ms 
ProteomicsHigh-throughput mixed-species quantitative benchmark with varying sample amounts
Samples were generated by mixing commercially available tryptic digests (human: K562, HeLa; yeast (S.cerevisiae); E.coli) in defined proportions, to create a dataset with known ground truth, for benchmarking of the quantitative performance and scalability of DIA raw data processing software. Acquisi...
ORGANISM(S): Homo sapiens (Human) Escherichia coli Saccharomyces cerevisiae (Baker's yeast) 
2025-12-09 | PXD055981 | Pride
UnknownEffect of Spermidine Analogues on Cell Growth of Escherichia coli Polyamine Requiring Mutant MA261.
Not available
S-EPMC4951125 | biostudies-literature
ProteomicsHigh-Throughput Label-free Single-Cell Proteomics Enabled by Multicolumn NanoLC with a 5-min Cycle Time
Mass spectrometry (MS)-based single-cell proteomics (SCP) enables proteome-wide analysis at single-cell resolution, offering insights into cellular heterogeneity, biological processes, and disease mechanisms. However, conventional nanoLC-MS workflows are constrained by long gradients and low through...
ORGANISM(S): Candida albicans (Yeast) Mus musculus (Mouse) Homo sapiens (Human) Escherichia coli 
2026-08-19 | PXD081782 | Pride
Single-cell proteomics High-throughput Multicolumn nanolc 
TranscriptomicsTranscription profiling of human immortalized, non-tumorigenic prostate epithelial cell line -time course of 1,25(OH)2D treated RWPE1 cells.
Background: Prostate cancer is the second leading cause of cancer mortality among US men. Epidemiological evidence suggests that high vitamin D status protects men from prostate cancer and the active form of vitamin D, 1α,25 dihydroxyvitamin D3 (1,25(OH)2D) has anti-cancer effects in cultured pro...
ORGANISM(S): Homo sapiens 
2010-01-19 | E-GEOD-15947 | biostudies-arrayexpress
TranscriptomicsTranscriptional analysis of follistatin influence on C2C12 mice myoblasts differentiation
Background: Follistatin (FS) is an activin-binding glycoprotein, known for its antagonistic action on the TGF-M-NM-2 super-family of cytokines. It has ability to prevent muscle atrophy and to stimulate muscle growth through binding of myostatin (GDF8). FS does not cause these changes only by inhibit...
ORGANISM(S): Mus musculus 
2014-10-31 | E-GEOD-59775 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human WT1-mutant versus WT1 wild-type Wilms tumors
Gain-of-function mutations in exon 3 of beta-catenin (CTNNB1) are specific for Wilms' tumors that have lost WT1, but 50% of WT1-mutant cases lack such "hot spot" mutations. To ask whether stabilization of beta-catenin might be essential after WT1 loss, and to identify downstream target genes, we com...
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-6120 | biostudies-arrayexpress
TranscriptomicsCTL-OA-OP human IT PF Bone - CompuGen H19K microarray study
Aims of study: (1) To identify systemic differences in osteoarthritic (OA) bone that contribute to OA pathogenesis. (2) Identify novel osteoporotic (OP) bone-related disease genes. Study involved comparison of trabecular bone extracted from the intertrochanteric (IT) region of the proximal femur (PF...
ORGANISM(S): Homo sapiens 
2008-01-14 | E-GEOD-8406 | biostudies-arrayexpress
TranscriptomicsExpression data from rat liver stem-like WB-F344 cells treated with 3,3’,4,4’,5-pentachlorobiphenyl (PCB 126)
Although the tumor promoting effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), coplanar polychlorinated biphenyls (PCBs) and related compounds in liver tissue are primarily attributed to activation of the aryl hydrocarbon receptor (AhR), the underlying molecular mechanisms are still unclear. Li...
ORGANISM(S): Rattus norvegicus 
2013-05-01 | E-GEOD-41902 | biostudies-arrayexpress
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