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Proteomics4E-BP1 counteracts human stem cell senescence via maintaining mitochondrial homeostasis
Although the mTOR-4E-BP1 signaling pathway is implicated in aging and aging-related disorders, the role of 4E-BP1 in regulating human stem cell homeostasis remains largely unknown. Here, we report that the expression of 4E-BP1 decreases along with the senescence of human mesenchymal stem cells (hMSC...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD033301 | Pride
Eif4ebp1 mitochondria oxidative phosphorylation 
Genomics4E-BP1-dependent translation in microglia controls mechanical hypersensitivity
4E-BP1-dependent translation in microglia controls mechanical hypersensitivity
PRJNA1205561 | ENA
GenomicsMitosis-related phosphorylation of the eukaryotic translation suppressor 4E-BP1 and its interaction with eukaryotic translation initiation factor 4E (eIF4E)
Mitosis-related phosphorylation of the eukaryotic translation suppressor 4E-BP1 and its interaction with eukaryotic translation initiation factor 4E (eIF4E)
PRJNA544328 | ENA
GenomicsTranslational control of mTOR/4E-BP1 axis in MiaPaca-2 cells
Translational control of mTOR/4E-BP1 axis in MiaPaca-2 cells
PRJNA565914 | ENA
TranscriptomicsMitosis-related phosphorylation of the eukaryotic translation suppressor 4E-BP1 and its interaction with eukaryotic translation initiation factor 4E (eIF4E)
Eukaryotic translation initiation factor 4E (eIF4E)–binding protein 1 (4E-BP1) inhibits cap-dependent translation in eukaryotes by competing with eIF4G for an interaction with eIF4E. Phos-phorylation at Ser-83 of 4E-BP1 occurs during mitosis through the activity of cyclin-dependent kinase 1 (CDK1)/c...
ORGANISM(S): Homo sapiens 
2019-06-14 | GSE131668 | GEO
Genomics4E-BP1-dependent translation in nociceptors controls mechanical hypersensitivity via TRIM32/type I interferon signaling
4E-BP1-dependent translation in nociceptors controls mechanical hypersensitivity via TRIM32/type I interferon signaling
PRJNA947609 | ENA
ProteomicsChromosome 8 gain drives cancer progression by hijacking the translational regulator 4E-BP1 sensitizing for targeted CDK4/6 inhibition
Chromosome 8 (chr8) gains are common in cancer. However, their potential contribution to tumor heterogeneity is largely unexplored. Ewing sarcoma (EwS) is characterized by pathognomonic FET::ETS fusions but a general paucity of other recurrent somatic mutations that could explain the observed clinic...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2025-09-22 | PXD065282 | Pride
Chromosome 8 gain 4e-bp1 ewing sarcoma Cdk4/6 inhibitor Chromosome 8 amplification Chromosome 8 copy number variation Eif4ebp1 
Other4E-BP1-dependent translation in microglia controls mechanical hypersensitivity
Spinal microglia play a pivotal role in the development of neuropathic pain. Peripheral nerve injury induces changes in the transcriptional profile of microglia, including increased expression of components of translational machinery. Whether microglial protein synthesis is stimulated following nerv...
ORGANISM(S): Mus musculus 
2024-01-31 | GSE254472 | GEO
Transcriptomics4E-BP1-dependent translation in microglia controls mechanical hypersensitivity
Spinal microglia play a pivotal role in the development of neuropathic pain. Peripheral nerve injury induces changes in the transcriptional profile of microglia, including increased expression of components of translational machinery. Whether microglial protein synthesis is stimulated following nerv...
ORGANISM(S): Mus musculus 
2025-02-25 | GSE285677 | GEO
TranscriptomicsTranslational control of mTOR/4E-BP1 axis in MiaPaca-2 cells
Pancreatic ductal adenocarcinoma (PDAC) relies on hyper-activated protein synthesis. Consistently, human and mouse PDAC lose expression of the translational repressor and mTOR target 4E-BP1. Using genome-wide polysome-profiling, we here explore mRNAs whose translational efficiencies depend on the mT...
ORGANISM(S): Homo sapiens 
2019-09-18 | GSE137553 | GEO
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