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UnknownHigh 4E-BP1 expression associates with chromosome 8 gain and CDK4/6 sensitivity in Ewing sarcoma.
Not available
S-EPMC12700544 | biostudies-literature
ProteomicsChromosome 8 gain drives cancer progression by hijacking the translational regulator 4E-BP1 sensitizing for targeted CDK4/6 inhibition
Chromosome 8 (chr8) gains are common in cancer. However, their potential contribution to tumor heterogeneity is largely unexplored. Ewing sarcoma (EwS) is characterized by pathognomonic FET::ETS fusions but a general paucity of other recurrent somatic mutations that could explain the observed clinic...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2025-09-22 | PXD065282 | Pride
Chromosome 8 gain 4e-bp1 ewing sarcoma Cdk4/6 inhibitor Chromosome 8 amplification Chromosome 8 copy number variation Eif4ebp1 
UnknownThe translational repressor 4E-BP1 regulates RRM2 levels and functions as a tumor suppressor in Ewing sarcoma tumors.
Not available
S-EPMC7856031 | biostudies-literature
UnknownmTORC1/2 and Protein Translation Regulate Levels of CHK1 and the Sensitivity to CHK1 Inhibitors in Ewing Sarcoma Cells.
Not available
S-EPMC6279492 | biostudies-literature
UnknownAuranofin and reactive oxygen species inhibit protein synthesis and regulate the level of the PLK1 protein in Ewing sarcoma cells.
Not available
S-EPMC11199525 | biostudies-literature
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