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MetabolomicsCapsaicin ameliorates glycemic levels via gut microbiota-derived 5-aminolevulinic acid in mice

Background: Capsaicin, a natural alkaloid in chili peppers, regulates glycemic levels, however, its mechanisms and therapeutic potential remain unclear. This study aimed to elucidate the role of gut microbiota and their metabolites in mediating capsaicin’s glycemic regulatory effects. We conducte...

2025-06-13 | MTBLS12575 | MetaboLights
GenomicsEvaluation of 5-aminolevulinic acid-mediated radiodynamic therapy after single-dose irradiation in HT-29 xenografted mice
Evaluation of 5-aminolevulinic acid-mediated radiodynamic therapy after single-dose irradiation in HT-29 xenografted mice
PRJNA1330812 | ENA
GenomicsThe effect of 5-aminolevulinic acid on canine peripheral blood mononuclear cells
The effect of 5-aminolevulinic acid on canine peripheral blood mononuclear cells
PRJNA847171 | ENA
GenomicsTranscriptome profile analysis reveals putative molecular mechanisms of 5-aminolevulinic acid toxicity
Transcriptome profile analysis reveals putative molecular mechanisms of 5-aminolevulinic acid toxicity
PRJNA840868 | ENA
TranscriptomicsGATA-1 and heme regulate the erythroid cell transcriptome.
Alas2 gene encodes the rate-limiting enzyme in heme biosynthesis. CRISPR/Cas9-mediated ablation of two Alas2 intronic cis-elements strongly reduced GATA-1-induced Alas2 transcription, heme biosynthesis, and GATA-1 regulation of other vital constituents of the erythroid cell transcriptome. Bypassing ...
ORGANISM(S): Mus musculus 
2016-01-07 | E-GEOD-74371 | biostudies-arrayexpress
TranscriptomicsCharacterization of 5-aminolevulinic acid effects on radiotherapy using mouse tumor model.
B16-BL6 mouse melanoma that had been maintained in C57BL/6J mice were used to evaluate the 5-aminolevulinic acid (ALA) effects on radiotherapy. Mice were divided into 4 groups after implantation of B16-BL6 cells; (1) control group; (2) ALA treatment; (3) Xray treatment; (4) ALA and Xray treatment.
ORGANISM(S): Mus musculus 
2016-08-14 | GSE54718 | GEO
TranscriptomicsExpression data from Arabidopsis thaliana seedlings with reduced synthesis of 5-aminolevulinic acid
5-aminolevulinic acid (ALA) is the common precursor of all biological synthezised tetrapyrroles. Inhibition of ALA synthesis results in decreased amounts of chlorophylls, heme, siroheme and phytochrome. It was previously shown that 4 out of 5 Arabidopsis mutants uncoupling nuclear gene expression fr...
ORGANISM(S): Arabidopsis thaliana 
2011-04-01 | E-GEOD-27704 | biostudies-arrayexpress
ClinicalThe study on laparoscopic diagnosis of peritoneal dissemination of colorectal cancer with 5-aminolevulinic acid
Interventions: 5 Aminolevulinic acid Primary outcome(s): Positive predictive value in intraoperative photodynamic diagnosis using 5 aminolevulinic acid in colorectal peritoneal dissemination Study Design: Single arm Non-randomized
2645701 | ecrin-mdr-crc
TranscriptomicsCharacterization of 5-aminolevulinic acid effects on radiotherapy using mouse tumor model.
B16-BL6 mouse melanoma that had been maintained in C57BL/6J mice were used to evaluate the 5-aminolevulinic acid (ALA) effects on radiotherapy. Mice were divided into 4 groups after implantation of B16-BL6 cells; (1) control group; (2) ALA treatment; (3) Xray treatment; (4) ALA and Xray treatment. B...
ORGANISM(S): Mus musculus 
2016-08-14 | E-GEOD-54718 | biostudies-arrayexpress
Genomics5-Aminolevulinic acid suppresses the effector function of feline lymphocytes by reducing the mitochondrial membrane potential
5-Aminolevulinic acid suppresses the effector function of feline lymphocytes by reducing the mitochondrial membrane potential
PRJNA1077239 | ENA
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