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TranscriptomicsApplication of a low cost array-based technique - TAB-Array - for quantifying and mapping both 5mC and 5hmC at single base resolution.
5-hydroxymethylcytosine (5hmC), an oxidized derivative of 5-methylcytosine (5mC), has been implicated as an important epigenetic regulator of mammalian development. Current procedures use cost-prohibitive DNA sequencing methods to discriminate 5hmC from 5mC, limiting their accessibility to the scie...
ORGANISM(S): Homo sapiens 
2014-12-12 | E-GEOD-60225 | biostudies-arrayexpress
TranscriptomicsGenome-wide Regulation of 5hmC, 5mC and Gene Expression by Tet1 Hydroxylase in Mouse Embryonic Stem Cells (expression data)
DNA methylation of C5-cytosine (5mC) in the mammalian genome is a key epigenetic event that is critical for various cellular processes. However, how the genome-wide 5mC pattern is dynamically regulated remains a fundamental question in epigenetic biology. The TET family of 5mC hydroxylases, which co...
ORGANISM(S): Mus musculus 
2011-04-21 | E-GEOD-28530 | biostudies-arrayexpress
GenomicsGenome-wide Regulation of 5hmC, 5mC and Gene Expression by Tet1 Hydroxylase in Mouse Embryonic Stem Cells (bisulfite sequencing data)
DNA methylation of C5-cytosine (5mC) in the mammalian genome is a key epigenetic event that is critical for various cellular processes. However, how the genome-wide 5mC pattern is dynamically regulated remains a fundamental question in epigenetic biology. The TET family of 5mC hydroxylases, which co...
ORGANISM(S): Mus musculus 
2011-04-21 | E-GEOD-28533 | biostudies-arrayexpress
TranscriptomicsGenome-wide Regulation of 5hmC, 5mC and Gene Expression by Tet1 Hydroxylase in Mouse Embryonic Stem Cells (ChIP-seq data)
DNA methylation of C5-cytosine (5mC) in the mammalian genome is a key epigenetic event that is critical for various cellular processes. However, how the genome-wide 5mC pattern is dynamically regulated remains a fundamental question in epigenetic biology. The TET family of 5mC hydroxylases, which co...
ORGANISM(S): Mus musculus 
2011-04-21 | E-GEOD-28532 | biostudies-arrayexpress
GenomicsMeDIP analysis of 5mC and 5hmC marks in human ataxia-telangiectasia cerebellum
Genomic DNA was prepared, fragmented, and immunoprecipitated with antibodies specific for 5mC or 5hmC prior to standard sequencing. The neurodegenerative disease known as ataxia-telangiectasia (A-T) is caused by the absence of the ATM (A-T mutated) protein. A long-standing mystery surrounding A-T i...
ORGANISM(S): Homo sapiens 
2015-10-30 | E-GEOD-61133 | biostudies-arrayexpress
GenomicsEnvironment-dependent 5mC methylation profiling in Riccia fluitans.
5mC methylation profiling in Riccia fluitans.
PRJEB112071 | ENA
GenomicsStudy of 5mC-DNA, m6A-RNA and RNA-expression in HeLa and EB [5mC in RNAi-treated HeLa]
Study of 5mC-DNA, m6A-RNA and RNA-expression in HeLa and EB [5mC in RNAi-treated HeLa]
PRJNA1138728 | ENA
GenomicsMethylome of 5mC and 5hmC regulated by NEIL2
Methylome of 5mC and 5hmC regulated by NEIL2
PRJNA1002410 | ENA
UnknownMolecular basis of an atypical dsDNA 5mC/6mA bifunctional dioxygenase CcTet from Coprinopsis cinerea in catalyzing dsDNA 5mC demethylation.
Not available
S-EPMC11040006 | biostudies-literature
GenomicsStudy of 5mC-DNA, m6A-RNA and RNA-expression in HeLa, ES and EB [5mC in ES and EB]
Study of 5mC-DNA, m6A-RNA and RNA-expression in HeLa, ES and EB [5mC in ES and EB]
PRJNA903112 | ENA
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