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TranscriptomicsTNFAIP3 (A20) is a tumor suppressor gene in Hodgkin lymphoma and primary mediastinal B cell lymphoma
Classical Hodgkin lymphoma (cHL) is one of the most common malignant lymphomas. It is characterized by the presence of rare Hodgkin and Reed/Sternberg (HRS) cells embedded in an extensive inflammatory infiltrate. Constitutive activation of nuclear factor-kappaB (NF-kappaB) in HRS cells which transcr...
ORGANISM(S): Homo sapiens 
2010-05-20 | E-GEOD-15264 | biostudies-arrayexpress
TranscriptomicsTranscriptome of mouse mature B cell lines A20 transfected with membrane IgE
We report the effect on genes expression of membrane IgE expression in the mouse mature B cell line A20 Examination of 2 stable transfectants IgE+ compared to untranfected or membrane IgM+ control transfectants
ORGANISM(S): Mus musculus 
2015-02-17 | E-GEOD-64130 | biostudies-arrayexpress
TranscriptomicsTiled Array Experiment of Murine Gammaherpesvirus 68 Transcripts Upon TPA-Stimulated Reactivation From Latency
Murine A20 B cells harboring latent MHV68 were treated with TPA and RNA expression was examined over a 24 hour timecourse experiment. Study includes 4 samples- an untreated sample and reactivation samples isolated at 6, 12, and 24 hours after treatment of a latent MHV68+ B cell line with TPA.
ORGANISM(S): Mus musculus 
2012-02-16 | E-GEOD-35865 | biostudies-arrayexpress
TranscriptomicsSNP data from lymphoma samples
B cell non-Hodgkin's lymphoma (B-NHL) consists of different pathological entities that are frequently characterized by distinct genetic alterations. However, the knowledge on these genetic lesions in B-NHL is still limited. In order to obtain a more comprehensive view of genetic lesions in B-NHL, we...
ORGANISM(S): Homo sapiens 
2009-05-01 | E-GEOD-12906 | biostudies-arrayexpress
Transcriptomicssingle cell RNAseq of memory B cells in the context of rituximab-treated ITP patients
Rituximab (RTX) is widely used as a first-line therapeutic strategy in B cell-mediated autoimmune diseases. However, a large proportion of patients either do not respond to the treatment or relapse during B cell reconstitution. Primary immune thrombocytopenia (ITP) is a prototypic B cell mediated au...
ORGANISM(S): Homo sapiens 
2021-01-31 | E-MTAB-9955 | biostudies-arrayexpress
TranscriptomicsTranscriptome of mouse mature B cell lines A20 transfected with membrane IgE
We report the effect on genes expression of membrane IgE expression in the mouse mature B cell line A20
ORGANISM(S): Mus musculus 
2015-02-17 | GSE64130 | GEO
UnknownHepatitis B surface antigen impairs TLR4 signaling by upregulating A20 expression in monocytes.
Not available
S-EPMC11448406 | biostudies-literature
TranscriptomicsNOD2 and desease associated variant NOD2-L1007fsinsC dependent genomewide transcriptional regulation in stable Flp-In HEK cells
NOD2 is an intracellular receptor for the bacterial cell wall component muramyl dipeptide (MDP) and variants of NOD2 are associated with chronic inflammatory diseases of barrier organs e.g. Crohn disease, asthma and atopic eczema. It is known that activation of NOD2 induces a variety of inflammatory...
ORGANISM(S): Homo sapiens 
2013-01-01 | E-GEOD-22611 | biostudies-arrayexpress
GenomicsC/EBPα poises B cells for rapid reprogramming into iPS cells [ChIP-Seq]
C/EBPα induces transdifferentiation of B cells into macrophages at high efficiencies and enhances reprogramming into induced pluripotent stem cells (iPSCs) when co-expressed with Oct4, Sox2, Klf4 and Myc (OSKM). However, how C/EBPα accomplishes these effects is unclear. We now found that transient C...
ORGANISM(S): Mus musculus 
2013-11-17 | E-GEOD-52373 | biostudies-arrayexpress
GenomicsMus musculus
Transcriptome of mouse mature B cell lines A20 transfected with membrane IgE
PRJNA270231 | ENA
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