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MetabolomicsComparative NMR metabolomics of the responses of A2780 human ovarian cancer cells to clinically established Pt based drugs
Not available
ORGANISM(S): Homo sapiens 
ST002116 | MetabolomicsWorkbench
TranscriptomicsDifferences in gene expression in A2780C20 vs. A2780
Differences in gene expression in A2780C20 vs. A2780 and A2780 treated with temsirolimus at 24-hr and 48-hr. The A2780 are human ovarian carcinoma cellls were purchased to the European Collection of Cell Cultures (ECACC). The A2780CP20 are cisplatin resisatnt cells derived of the A2780 cells. A2780...
ORGANISM(S): Homo sapiens 
2013-10-25 | E-GEOD-51683 | biostudies-arrayexpress
TranscriptomicsExpression and metylation data from A2780 (cisplatin-sensitive) and Round5 A2780 (cisplatin-resistant) cell lines
This SuperSeries is composed of the following subset Series: GSE15372: Expression data from A2780 (cisplatin-sensitive) and Round5 A2780 (cisplatin-resistant) cell lines. GSE15373: Promoter CpG island methylation data from A2780 (cisplatin-sensitive) and Round5 A2780 (cisplatin-resistant) cell lines...
ORGANISM(S): Homo sapiens 
2009-04-17 | E-GEOD-15709 | biostudies-arrayexpress
TranscriptomicsA2780 and OVCAR-3 Cells:Control vs. LS-98 treated
Transcriptional profiling of human ovarian cancer cells comparing control vehicle-treated A2780 and OVCAR-3 (Human ovarian cancer cell lines) cells with A2780 and OVCAR-3 cells treated with 5μM LS-98 for 24 hours.Goal was to determine the effects of LS-98 compound on the global A2780 and OVCAR-3 ce...
ORGANISM(S): Homo sapiens 
2011-06-01 | E-GEOD-29668 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of the effects of the novel mithramycin analogue DIG-MSK on human A2780 ovarian carcinoma cells
The effects of demycarosyl-3D-M-NM-2-D-digitoxosyl-mithramycin SK (DIG-MSK; EC-8042), a novel analogue of the antitumor antibiotic mithramycin A, on gene transcription were examined in human A2780 ovarian carcinoma cells. DIG-MSK down-regulated a different set of genes depending on the drug concentr...
ORGANISM(S): Homo sapiens 
2014-08-13 | E-GEOD-46926 | biostudies-arrayexpress
TranscriptomicsFlavopiridol profiling on A2780
The effects of the CDK inhibitor Flavopiridol on the A2780 human adenocarcinoma ovary cell line were analysed by gene expression profiling. A2780 cells were treated with Flavopiridol for 6 hours at a dose equal to 5 times the IC50. Untreated A2780 cells were used as a control. Two replicates per tre...
ORGANISM(S): Homo sapiens 
2010-07-14 | E-GEOD-18504 | biostudies-arrayexpress
GenomicsRNA seq analysis of A2780 and A2780-ADR
RNA seq analysis of A2780 and A2780-ADR
PRJNA736941 | ENA
TranscriptomicsPromoter CpG island methylation data from A2780 (cisplatin-sensitive) and Round5 A2780 (cisplatin-resistant) cell lines.
Cisplatin and carboplatin are the primary first-line therapies for the treatment of ovarian cancer. However, resistance to these platinum-based drugs occurs in the large majority of initially responsive tumors, subsequently resulting in a poor long-term prognosis. To model the onset of drug resista...
ORGANISM(S): Homo sapiens 
2010-06-19 | E-GEOD-15373 | biostudies-arrayexpress
TranscriptomicsDifferential gene expression for A2780 human ovarian cancer cells when exposed to a new osmium-based anticancer agent
Platinum-based metallodrugs are the most widely used anticancer agents. Their reduced effectiveness after repeat dosing (resistance) constitutes a major clinical problem. In this experiment we study a potent organo-osmium compound with improved activity over cisplatin and no cross-resistance in plat...
ORGANISM(S): Homo sapiens 
2016-05-22 | E-MTAB-2758 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of human A2780 ovarianc cancer cells and cisplatin resistant derivate cells treated with cisplatin or liposomal cisplatin
A2780 ovarian cancer cells and a cisplatin resistant derivate of A2780 cells, obtained from ECACC, UK, No. 93112519 [A2780] and No. 93112517 [A2780 cis] were seeded out in T-75 flasks at a density of 2x106 for A2780sens and 3x106 for A2780cis cells in 15 ml of medium and preincubated overnight. Medi...
ORGANISM(S): Homo sapiens 
2010-12-13 | E-MEXP-2840 | biostudies-arrayexpress
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