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MetabolomicsSearching for Drug Synergy Against Cancer Through Polyamine Metabolism Impairment: Insight Into the Metabolic Effect of Indomethacin on Lung Cancer Cells
Non-small cell lung cancer (NSCLC) is the most lethal and prevalent type of lung cancer. In almost all types of cancer, the levels of polyamines (putrescine, spermidine, and spermine) are increased, playing a pivotal role in tumor proliferation. Indomethacin, a non-steroidal anti-inflammatory drug, ...
2021-02-08 | MTBLS873 | MetaboLights
TranscriptomicsTranslatome of A549, H1299 and HBE cells
We performed translatome and transcriptome sequencing of A549, H1299 and HBE cells and analyzed the translation ratio (TR) of all genes Total RNA and ribosome-bound RNA were extracted from A549, H1299 and HBE cells, and the polyA+ mRNA was sequenced using Illumina GAIIx and HiSeq-2000. The reads wer...
ORGANISM(S): Homo sapiens 
2013-03-05 | E-GEOD-42006 | biostudies-arrayexpress
TranscriptomicsMETTL3 promotes translation in human cancer cells
we find METTL3 associates with polyribosomes and promotes translation. METTL3 depletion inhibits translation, and both wild-type and catalytically inactive METTL3 promote translation when tethered to the 3' untranslated region (UTR) of a reporter mRNA. Mechanistically, METTL3 enhances mRNA translati...
ORGANISM(S): Homo sapiens 
2016-07-03 | E-GEOD-76367 | biostudies-arrayexpress
TranscriptomicsExpression data regulated by hMOF in non-small cell lung cancer (NSCLC) cell lines
A549 and H1299 cell lines were transfected with hMOF specific siRNA or control siRNA, and Affymetrix oligonucleotide microarray was conducted to systematically determine downstream targets regulated by hMOF. Two NSCLC cell lines (four samples) transfected with hMOF specific siRNA or control siRNA
ORGANISM(S): Homo sapiens 
2012-08-29 | E-GEOD-40424 | biostudies-arrayexpress
UnknownGATA3 Exerts Distinct Transcriptional Functions to Regulate Radiation Resistance in A549 and H1299 Cells.
Not available
S-EPMC9385326 | biostudies-literature
TranscriptomicsTranslatome of A549, H1299 and HBE cells
We performed translatome and transcriptome sequencing of A549, H1299 and HBE cells and analyzed the translation ratio (TR) of all genes
ORGANISM(S): Homo sapiens 
2013-03-05 | GSE42006 | GEO
TranscriptomicsH3K9K14ac ChIP-chip in lung cancer cells treated with histone deacetylase inhibitor
Lung cancer is the leading cause of cancer mortality worldwide, yet the therapeutic strategy for advanced non-small cell lung cancer (NSCLC) is limitedly effective. In addition, validated histone deacetylase (HDAC) inhibitors for the treatment of solid tumors remain to be developed. Here, we propose...
ORGANISM(S): Homo sapiens 
2010-12-22 | E-GEOD-20304 | biostudies-arrayexpress
GenomicsHomo sapiens
Translatome of A549, H1299 and HBE cells
PRJNA178748 | ENA
UnknownCalotropis gigantea extract induces apoptosis through extrinsic/intrinsic pathways and reactive oxygen species generation in A549 and NCI-H1299 non-small cell lung cancer cells.
Not available
S-EPMC6582476 | biostudies-literature
UnknownThe Role of the LINC01376/miR-15b-3p_R-1/FGF2 Axis in A549 and H1299 Cells EMT Induced by LMW-PAHs.
Not available
S-EPMC12846051 | biostudies-literature
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