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ProteomicsHeLa phosphoproteome regulated by PP2A related proteins
HeLa cells were treated with siRNAs of PP2A related proteins or with okadaic acid, in triplicates. Tryptic digests of extracted proteins were analyzed using a Q Exactive mass spectrometer, before and after TiO2 phosphopeptide enrichment. Data were searched with Mascot via Proteome Discoverer. For ph...
ORGANISM(S): Homo Sapiens (human) 
2020-02-19 | PXD016102 | JPOST Repository
TranscriptomicsThe effect of miRNA overexpression on gene expression profile of MCF-7 cells
To identify microRNAs impacting estrogen receptor ERα expression in breast cancer, we have screened ER-positive breast cancer cells with a library of pre-miRs, and systematically monitored the ERα expression by protein lysate microarrays. There was a significant enrichment of the in silico predict...
ORGANISM(S): Homo sapiens 
2010-04-09 | E-GEOD-14847 | biostudies-arrayexpress
ProteomicsPP2A inhibition is a druggable MEK inhibitor resistance mechanism in KRAS-mutant lung cancer cells
TiO2-enriched and non-enriched samples and a pooled TiO2-enriched alkaline phosphatase treated sample from subconfluent A549 lung adenocarcinoma cells line. Cells were subjected to on of the 6 different treatments: Control sample, RNAi mediated depletion of PPP2R1A, CIP2A, or PME-1, and treatment w...
ORGANISM(S): Homo sapiens (Human) 
2018-10-11 | PXD009900 | Pride
Phosphoproteomics Pp2a A549 Lung cancer 
UnknownPeroxisome proliferator-activated receptor-gamma regulates the expression and function of very-low-density lipoprotein receptor.
Not available
S-EPMC2806108 | biostudies-literature
UnknownPP2A inhibition is a druggable MEK inhibitor resistance mechanism in KRAS-mutant lung cancer cells.
Not available
S-EPMC8335581 | biostudies-literature
UnknownMicroRNA-135b regulates ERα, AR and HIF1AN and affects breast and prostate cancer cell growth.
Not available
S-EPMC5528813 | biostudies-literature
UnknownRAS and PP2A activities converge on epigenetic gene regulation.
Not available
S-EPMC9979842 | biostudies-literature
UnknownPP2A methylesterase PME-1 suppresses anoikis and is associated with therapy relapse of PTEN-deficient prostate cancers.
Not available
S-EPMC10257411 | biostudies-literature
ProteomicsStructural mechanism for inhibition of PP2A-B56 and oncogenicity by CIP2A
Abstract The protein phosphatase 2A (PP2A) heterotrimer PP2A-B56 is a human tumor suppressor. However, the molecular mechanisms inhibiting PP2A-B56in cancer are poorly understood. Here, we report molecular level details and structural mechanism of PP2A-B56inhibition by an oncoprotein CIP2A. Upon di...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-11 | PXD030297 | Pride
Ap-ms Protein phosphatase Mouse Oncogene Interactome 
UnknownStructural mechanism for inhibition of PP2A-B56α and oncogenicity by CIP2A.
Not available
S-EPMC9974998 | biostudies-literature
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