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TranscriptomicsPU.1 regulates T-lineage gene expression and progression via indirect repression during early T-cell development
The Ets family transcription factor PU.1 is essential for the development and maintenance of several hematopoietic lineages. In the thymus, PU.1 is expressed only in the early ETP/DN1, DN2a and DN2b stages of development. While PU.1 deletion in multipotent precursors leads to a complete block in T-c...
ORGANISM(S): Mus musculus 
2015-04-08 | E-GEOD-65344 | biostudies-arrayexpress
TranscriptomicsHuman T cells isolated from healthy European and African American blood donors: Control vs. Interferon alpha 2b-treated
Transcriptional profiling of human T cells analyzing the impact of race on the responsiveness to IFNa in healthy blood donors. Control and IFNa-treated samples derived from healthy Caucasian American vs. African American blood donors are compared. Two-condition experiment, Control vs. IFNa-treated. ...
ORGANISM(S): Homo sapiens 
2010-05-16 | E-GEOD-17952 | biostudies-arrayexpress
MetabolomicsSkeletal muscle metabolomics and blood biochemistry analysis reveal metabolic changes associated with dietary amino acid supplementation in dairy calves
The effects of different amino acid (AA) supplementations of milk protein-based milk replacers in pre-ruminant calves from 3 days to 7 weeks of age were studied. Animals were divided into 4 groups: Ctrl) Control group fed with milk protein-based milk replacer without supplementation; GP) supplementa...
2018-10-08 | MTBLS720 | MetaboLights
TranscriptomicsDifferential Gene Expression between African American and European American Colorectal Cancer Patients
The incidence and mortality of colorectal cancer (CRC) is higher in African Americans (AAs) than in other ethnic groups in the U. S., but reasons for the disparities are unknown. We performed gene expression profiling and microsatellite instability (MSI) analysis of sporadic CRCs from AAs vs. Europe...
ORGANISM(S): Homo sapiens 
2012-05-22 | E-GEOD-28000 | biostudies-arrayexpress
GenomicsDistinct phenotypes and repertoires of bronchoalveolar and airway mucosal T cells in health and allergic asthma
Distinct phenotypes and repertoires of bronchoalveolar and airway mucosal T cells in health and allergic asthma
PRJNA1308187 | ENA
GenomicsDistinct phenotypes and repertoires of bronchoalveolar and airway mucosal T cells in health and allergic asthma
Distinct phenotypes and repertoires of bronchoalveolar and airway mucosal T cells in health and allergic asthma
PRJNA1308188 | ENA
TranscriptomicsDistinct phenotypes and repertoires of bronchoalveolar and airway mucosal T cells in health and allergic asthma
T cells play a central role in host protection against respiratory pathogens, but a maladaptive T cell response can lead to pulmonary diseases. Defining the biology of protective versus pathogenic T cell responses in the lungs of humans will be critical to nominate novel approaches to improve respir...
ORGANISM(S): Homo sapiens 
2026-03-10 | GSE297584 | GEO
GenomicsDistinct phenotypes and repertoires of bronchoalveolar and airway mucosal T cells in health and allergic asthma
Distinct phenotypes and repertoires of bronchoalveolar and airway mucosal T cells in health and allergic asthma
PRJNA1265215 | ENA
UnknownGlutamine promotes human CD8+ T cells and counteracts imiquimod-induced T cell hyporesponsiveness.
Not available
S-EPMC11088342 | biostudies-literature
TranscriptomicsPU.1 regulates T-lineage gene expression and progression via indirect repression during early T-cell development
The Ets family transcription factor PU.1 is essential for the development and maintenance of several hematopoietic lineages. In the thymus, PU.1 is expressed only in the early ETP/DN1, DN2a and DN2b stages of development. While PU.1 deletion in multipotent precursors leads to a complete block in T-c...
ORGANISM(S): Mus musculus 
2015-04-08 | GSE65344 | GEO
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