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Peripheral vascular strand development in nodules is controlled by a bHLH/HLH heterodimer
Background: Severe combined immunodeficiency (SCID) is characterized by arrested T lymphocyte production and B lymphocyte dysfunction, resulting in life-threatening infections. Early diagnosis of SCID through population-based newborn screening (NBS) optimizes clinical management and outcomes, and al...
ORGANISM(S): Homo sapiens 
The Hedgehog (Hh) pathway is essential for organ development, homeostasis, and regeneration. Dysfunction of this cascade drives several cancers. To control expression of pathway target genes, the G protein-coupled receptor (GPCR) Smoothened (SMO) activates glioma-associated (GLI) transcription facto...
ORGANISM(S): Homo Sapiens 
Fresh tumor tissue from primary endometrial tumors. Technology: L1000 is an array based technology that measured 978 landmark genes that are extrapolated using an algorithm to generate a transcription profile of 12,328 genes. Reference L1000 technology: Subramanian A, et al. A Next Generation Conne...
ORGANISM(S): Homo sapiens 
Patient-derived endometrial cancer organoids. The data was used to compare gene expression profile between organoids, and to explore whether an organoid-derived gene signature could predict disease outcomes in independent patient cohorts.
ORGANISM(S): Homo sapiens 
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