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Single-nucleotide resolution mapping of DNA abasic sites by snAP-seq
Genome-wide profiling reveals the distribution pattern of abasic sites in mammalian genomes
Abasic (AP) sites are one of the most common forms of DNA damage which can lead to polymerase stalling, strand breaks and mutations. We developed snA-seq, a mapping method that reveals the location of abasic sites at base-resolution. Using synthetic DNA, we show that high selectivity for AP DNA is a...
ORGANISM(S): Leishmania major 
The AP-seq provides a genome-wide method for detecting abasic sites among the human and mouse genomes Purpose: Abasic sites are one of the most frequent DNA damage among the genome , which often carries harmful consequences for the genome stability and the normal cell functions. So it is necessary t...
ORGANISM(S): Homo sapiens Mus musculus 
2020-12-01 | GSE125254 | GEO
Genomics
RNA Abasic Sites in Yeast and Human Cells
SPECIFIC REACTIVITY OF ABASIC SITES WITH POLYAMINES ENABLES THEIR GENOMIC MAPPING
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