Sort   by:  
 Page size 
ProteomicsIntegrated Phenotypic and Activity-Based Profiling of Electrophilic Fragments Reveals New Targets for Antibiotics Development
The emergence of antibiotic resistance necessitates the discovery of novel bacterial targets and antimicrobial agents. Here, we present a bacterial target discovery framework that integrates phenotypic screening of cysteine-reactive fragments with competitive activity-based protein profiling to map ...
ORGANISM(S): Shigella flexneri S5644 Bacteria 
2025-05-07 | PXD058002 | Pride
Phenotypic screening  covalent inhibitor  antibiotics  activity-based protein profiling  fabh  miaa  pdxy 
ProteomicsBiomimetic Synthesis and Chemical Proteomics Reveal the Mechanism of Action and Functional Targets of Lysine-Reactive Phloroglucinol Meroterpenoids
Natural products have long been an enduring source of drug leads and chemical probes that have led to the development of numerous medicines. Despite their scarcity, the discovery of natural products that modulate protein function through covalent interactions with lysine residues holds immense poten...
ORGANISM(S): Homo sapiens (Human) 
2024-05-23 | PXD045370 | Pride
Mitochondrial respiration. Lipid metabolism Lysine conjugation Activity-based protein profiling Natural products Glycolysis Chemical proteomics Phloroglucinol meroterpenoids 
ProteomicsPrecision Chemistry and Activity-Based Proteomics for Posttranslational Control of Protein Function
Lysine acylations are ubiquitous and structurally diverse posttranslational modifications that vastly expand the functional heterogeneity of the human proteome. Hence, the targeted acylation of lysine residues has emerged as a strategic approach to exert biomimetic control over protein function. How...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD051414 | Pride
Retinoid metabolism. Posttranslational modifications Lysine conjugation Protein-rna interactions Chemoproteomics Activity-based protein profiling N-(cyanomethyl)-n-(phenylsulfonyl)amides 
Sort   by:  
 Page size