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TranscriptomicsTranscription profiling of human GFAP-negative lamina cribrosa cells TGF-beta regulated gene transcription and protein expression
Primary open angle glaucoma (POAG) is a progressive optic neuropathy, which is a major cause of worldwide visual impairment and blindness. Pathological hallmarks of the glaucomatous optic nerve head include retinal ganglion cell axon loss and extracellular matrix (ECM) remodeling of the lamina cribr...
ORGANISM(S): Homo sapiens 
2008-06-12 | E-GEOD-2705 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human lamina cribrosa cells in vitro treated with mechanical strain
The mechanical effect of raised intraocular pressure is a recognised stimulus for optic neuropathy in primary open angle glaucoma (POAG). Characteristic extra-cellular matrix (ECM) remodelling accompanies axonal damage in the lamina cribrosa (LC) of the optic nerve head in POAG. Glial cells in the l...
ORGANISM(S): Homo sapiens 
2008-06-12 | E-GEOD-3166 | biostudies-arrayexpress
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