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ProteomicsUnified workflow for the rapid and in-depth characterization of bacterial proteomes
Among the kingdoms of life, bacteria are by far the most abundant, but also the most diverse organisms. Due to this excessive diversity, finding a unified, comprehensive and safe workflow for quantitative bacterial proteomics is highly challenging. In this study, we have systematically evaluated and...
ORGANISM(S): Bacillus Subtilis (ncbitaxon:1423) Enterococcus Faecalis (ncbitaxon:1351) Vibrio Proteolyticus (ncbitaxon:671) Lactobacillus Delbrueckii (ncbitaxon:1584) Burkholderia Cepacia (ncbitaxon:292) Streptococcus Mitis (ncbitaxon:28037) Staphylococcus Aureus (ncbitaxon:1280) Escherichia Coli (ncbitaxon:562) Bifidobacterium Bifidum (ncbitaxon:1681) Sphingobacterium Spiritivorum (ncbitaxon:258) Deinococcus Radiodurans (ncbitaxon:1299) Prevotella Melaninogenica (ncbitaxon:28132) Micrococcus Luteus (ncbitaxon:1270) Cutibacterium Acnes (ncbitaxon:1747) Brevundimonas Diminuta (ncbitaxon:293) Pseudomonas Aeruginosa (ncbitaxon:287) Anoxybacillus Flavithermus (ncbitaxon:33934) Acetobacter Aceti (ncbitaxon:435) Mycolicibacterium Smegmatis (ncbitaxon:1772) Listeria Monocytogenes (ncbitaxon:1639) Clostridium Sporogenes (ncbitaxon:1509) Bacillus Cereus (ncbitaxon:1396) Corynebacterium Glutamicum (ncbitaxon:1718) 
2023-01-18 | MSV000091088 | MassIVE
ProteomicsProteomic diversity in bacteria: Insights and implications for bacterial identification
We acquired the largest bacterial proteomic resource, covering 303 species, 119 genera, and five phyla. The proteome coverage is, on average, over 50%. Additionally, we acquired further datasets for bacterial identification algorithm validation: i) 303 species at a 30-minute gradient (38 samples per...
ORGANISM(S): Bacteria (ncbitaxon:2) 
2024-12-06 | MSV000096603 | MassIVE
ProteomicsDecrypting lysine deacetylase inhibitor action and protein modifications by dose-resolved proteomics
Lysine deacetylase inhibitors (KDACis) are approved drugs for cutaneous T-cell lymphoma (CTCL) and multiple myeloma. The drugs lead to increasing acetylation levels of histones and other proteins, altered gene expression, and cell death. To characterize the mechanisms of action of these drugs in mor...
ORGANISM(S): Homo Sapiens 
PXD047419 | panorama
ProteomicsDose-dependent proteome profiling of KRAS pathway inhibitors sheds new light on drug mechanism of action and KRAS signaling
Kras is a molecular switch controlling the activity of the MAPK pathway. As such, it determines ERK activation state. In this study we identified many novel p-sites that were regulated upon KRAS inhibition. Many of these regulated p-sites were located within a SP/TP motif, the recognition motif of p...
ORGANISM(S): Homo Sapiens 
PXD054509 | panorama
ProteomicsMitochondrial damage drives T-cell immunometabolic paralysis after major surgery
Cytotoxic T cell (CTL) dysfunction is a key feature of immune paralysis following major surgery, significantly increasing the risk of severe nosocomial infections and contributing to elevated mortality in critically ill patients. The pathomechanisms of CTL dysfunction remain unclear. We report that ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2025-02-04 | MSV000097035 | MassIVE
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