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TranscriptomicsTranscription profiling of mouse Abl pre-B cell lines with conditional deletion of dicer
Abelson virus (v-Abl)-transformed pre-B cell lines from BM of dcrfl/fl; R26R-yfp (4470; 4475) and dcrfl/+; R26R-yfp mice (4483) are treated with a transducible Cre protein (Tat-Cre) to induce deletion of the dicer-1 gene in vitro. Cre activity is conveniently monitored by concomitant expression of Y...
ORGANISM(S): Mus musculus 
2008-03-08 | E-MEXP-1455 | biostudies-arrayexpress
ProteomicsIn depth mapping of DNA-PKcs and ATM kinase signaling responses to double strand breaks.
In depth analysis of double strand break signaling was performed using mouse Pre-B cells and Human HCT116 cells. Our analysis included the induction of double strand breaks with ionizing radiation with the addition of ATM and DNA-PKcs inhibitors, alone and in combination.
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2024-10-17 | PXD042258 | Pride
G1 arrest Lc-ms/ms Dna repair Human Mouse Abelson pre-b cells Ionizing radiation 
TranscriptomicsHairpin Capture of DNA End Structures reveals chromosomal DNA end structure with single nucleotide resolution
The structure of broken DNA ends is a critical determinant of the pathway used for DNA double strand break (DSB) repair. Here, we develop an approach, hairpin capture of DNA end structures (HCoDES), which elucidates chromosomal DNA end structures at single nucleotide resolution. HCoDES defines str...
ORGANISM(S): Mus musculus 
2014-12-03 | E-GEOD-62534 | biostudies-arrayexpress
UnknownClarifying the role of Stat5 in lymphoid development and Abelson-induced transformation.
Not available
S-EPMC2875852 | biostudies-literature
UnknownA small molecular compound CC1007 induces cross-lineage differentiation by inhibiting HDAC7 expression and HDAC7/MEF2C interaction in BCR-ABL1- pre-B-ALL.
Not available
S-EPMC7483467 | biostudies-literature
GenomicsHTGTS for Linear RAG Scanning Mediates Editing of Igκ Variable Region Repertoires
We performed HTGTS-V(D)J-seq in BM B cells and v-Abl transformed pro-B cells and its various mutant derivatives to study the molecular mechanisms of Igk secondary V(D)J recombination.
ORGANISM(S): Mus musculus 
2026-02-23 | E-MTAB-16001 | biostudies-arrayexpress
GenomicsRAG Represents a Widespread Threat to the Lymphocyte Genome - (ChIP-seq)
The RAG1 endonuclease, together with its cofactor RAG2, is essential for V(D)J recombination but is a potent threat to genome stability. The sources of RAG1 mistargeting and the mechanisms that have evolved to suppress it are poorly understood. Here, we report the surprising finding that RAG1 bind...
ORGANISM(S): Mus musculus 
2015-08-06 | E-GEOD-69475 | biostudies-arrayexpress
TranscriptomicsChromatin signature identifies monoallelic gene expression across mammalian cell types (RNA-seq)
Monoallelic expression of autosomal genes (MAE) is a widespread epigenetic phenomenon which is poorly understood, due in part to current limitations of genome-wide approaches for assessing it. Recently, we reported that a specific histone modification signature is strongly associated with MAE, and d...
ORGANISM(S): Mus musculus 
2015-06-17 | E-GEOD-67379 | biostudies-arrayexpress
UnknownmiR290-5p/292-5p activate the immunoglobulin kappa locus in B cell development.
Not available
S-EPMC3426528 | biostudies-literature
TranscriptomicsATAC-seq for Linear RAG Scanning Mediates Editing of Igκ Variable Region Repertoires
We performed ATAC-seq in v-Abl transformed pro-B cells and its various mutant derivatives to study the differential molecular mechanisms of Igk secondary V(D)J recombination.
ORGANISM(S): Mus musculus 
2026-02-23 | E-MTAB-16602 | biostudies-arrayexpress
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