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ProteomicsThe novel pre-rRNA detection workflow “Riboprobing” identified a hitherto undescribed aberrant pre-rRNA
Ribosomes translate mRNA into proteins and are essential for every living organism. In eukaryotes both ribosomal subunits are rapidly assembled in a strict hierarchical order, starting in the nucleolus with transcription of a common precursor ribosomal RNA (pre-rRNA). This pre-rRNA encodes three of ...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2025-04-29 | PXD047506 | Pride
Aberrant pre-rrna Primer extension Ribosome biogenesis Reverse transcription Pre-rrna processing 
ProteomicsNuclear VCP-like 2 (NVL2)-associated complex
LC-MSMS analysis of NVL2-associated pre-60S complex. To obtain more insights into the molecular mechanism of this effects caused by the mutant NVL2 in pre-60S complexes,we searched for additional proteins that preferentially interact with the NVL2(E365Q/E682Q) in comparison with wild-type NVL2. Co-m...
ORGANISM(S): Homo Sapiens (human) 
2025-01-31 | PXD057741 | JPOST Repository
Transcriptomicsapum23_col3
Gene expression analyses of three-week old soil grown wild-type (Col-3) and apum23-1 mutant. Expression profiling was conducted as an attempt to identify the genes differentially regulated in apum23-1 mutant This study was under taken to characterize a member of pumilio family, APUM23 in Arabidopsis...
ORGANISM(S): Arabidopsis thaliana 
2011-03-01 | E-GEOD-23940 | biostudies-arrayexpress
Unknown5'-end surveillance by Xrn2 acts as a shared mechanism for mammalian pre-rRNA maturation and decay.
Not available
S-EPMC3061060 | biostudies-literature
UnknownLa Deletion from Mouse Brain Alters Pre-tRNA Metabolism and Accumulation of Pre-5.8S rRNA, with Neuron Death and Reactive Astrocytosis.
Not available
S-EPMC5477551 | biostudies-literature
UnknownYeast polypeptide exit tunnel ribosomal proteins L17, L35 and L37 are necessary to recruit late-assembling factors required for 27SB pre-rRNA processing.
Not available
S-EPMC3561946 | biostudies-literature
UnknownTurnover of aberrant pre-40S pre-ribosomal particles is initiated by a novel endonucleolytic decay pathway.
Not available
S-EPMC5961177 | biostudies-literature
TranscriptomicsFunctional analysis of HD2C in Arabidopsis
Ribosome biogenesis is a fundamental process required for all cellular activities. Histone deacetylases play critical roles in many biological processes including transcriptional repression and rDNA silencing. However, their function in pre-rRNA processing remains poorly understood. Here, we discove...
ORGANISM(S): Arabidopsis thaliana 
2018-03-01 | GSE107883 | GEO
TranscriptomicsThe nucleolar protein NOL12 is required for processing of large ribosomal subunit rRNA precursors in Arabidopsis
NOL12 5'-3' exoribonucleases, conserved among eukaryotes, play important roles in pre-rRNA processing, ribosome assembly and export. The most well-described yeast counterpart, Rrp17, is required for maturation of 5.8 and 25S rRNAs, whereas human hNOL12 is crucial for the separation of the large (LSU...
ORGANISM(S): Arabidopsis thaliana 
2023-11-07 | GSE232067 | GEO
TranscriptomicsURB1 ensures 3' end processing of pre-rRNAs to prevent exosome-dependent degradation and is required for development
The nucleolus composes hundreds of proteins that play distinct roles in ribosomal RNA (rRNA) processing within Fibrillar Center/Dense Fibrillar Component (FC/DFC) units and ribosome assembly in Granular Component (GC). The sub-nucleolar localization of most proteins and how their unique localization...
ORGANISM(S): Homo sapiens 
2023-01-04 | GSE194413 | GEO
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