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TranscriptomicsGene-expression profiles of IFN-gamma-affected HOSE cells
The source of IFN-γ in ovarian cancer microenvironment and its biological effect to the tumor cells is unclear. The immortalized human ovarian surface epithelial cell line, HOSE-E7/hTERT (HOSE) was treated with IFN-γ and expression microarray analysis was performed, and probes showing significantl...
ORGANISM(S): Homo sapiens 
2014-03-04 | E-GEOD-55510 | biostudies-arrayexpress
TranscriptomicsGene-expression profiles of ovarian cancer regarding its microenvironment
PD-L1 suppresses host immunity and promotes tumor growth. We investigated how IFN-? regulates PD-L1 in the ovarian cancer microenvironment. In clinical samples, the number of stromal CTLs in peritoneally disseminated tumors was correlated with PD-L1 expression on the tumor cells, and the lymphocyte...
ORGANISM(S): Homo sapiens 
2014-03-04 | E-GEOD-55512 | biostudies-arrayexpress
TranscriptomicsGene-expression profiles of ascites-cytology-positive ovarian cancer
Ovarian cancer often progresses by disseminating to the peritoneal cavity, but how the tumor cells evade host immunity during this process is poorly understood. Programmed cell death 1 ligand 1 (PD-L1) is known to suppress immune system and to be an unfavorable prognostic factor in ovarian cancer. T...
ORGANISM(S): Homo sapiens 
2012-07-09 | E-GEOD-39204 | biostudies-arrayexpress
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