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TranscriptomicsSingle cell RNA-seq of immune cells isolated from lymphoid organs of Aire-deficient and wild-type control mice
Autoimmune regulator (Aire) orchestrates the display of peripheral self-antigens to T cells developing in the thymus, thereby playing a crucial function in the induction of immune tolerance. Mice lacking Aire develop multiorgan autoimmunity, but how that reflects on immune cells in the major lymphoi...
ORGANISM(S): Mus musculus 
2025-10-30 | E-MTAB-14774 | biostudies-arrayexpress
TranscriptomicsGene Expression Profile of Medullary Epithelial Cells isolated from thymus of Bone Marrow (BM) reconstituted RAG1 null (control) and SCID NOD mouse
We identified DNAPK as one of the major proteins that physically interact with Autoimmune regulator (Aire). To establish physiological significance of DNAPK in Aire-driven expression of PTA genes in MECs, we utilized BM-reconstituted SCID mice (which express non functional DNAPK in their MECs) and R...
ORGANISM(S): Mus musculus 
2010-10-16 | E-GEOD-24734 | biostudies-arrayexpress
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