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MetabolomicsComprehensive analysis of the microbiome and metabolome in pus from pyogenic liver abscess patients with and without diabetes mellitus

Pyogenic liver abscess (PLA) patients combined with diabetes mellitus (DM) tend to have more severe clinical manifestations than without DM. The mechanism responsible for this phenomenon is not entirely clear. The current study therefore aimed to comprehensively analyze the microbiome composition...

2026-01-24 | MTBLS7128 | MetaboLights
MetabolomicsIdentification of BolA protein reveals a novel virulence factor in Klebsiella pneumoniae that contributes to liver abscess in mice

BolA has been characterized as an important transcriptional regulator, which is induced in the stationary phase of growth and is often associated with bacterial virulence. This study was initiated to elucidate the role of the BolA in the virulence of K. pneumoniae. Using a mous...

2022-09-13 | MTBLS2712 | MetaboLights
TranscriptomicsNeutrophil-derived IL-1β is sufficient for abscess formation in immunity against Staphylococcus aureus in mice
Neutrophil abscess formation is critical in innate immunity against many pathogens. Here, the mechanism of neutrophil abscess formation was investigated using a mouse model of Staphylococcus aureus cutaneous infection. Gene expression analysis of S. aureus-infected skin revealed that induction of ne...
ORGANISM(S): Mus musculus 
2012-12-05 | E-GEOD-36826 | biostudies-arrayexpress
ProteomicsComparative Proteomic Analysis of Fusobacterium nucleatum Clinical Isolates from Brain Abscess Patients versus the Standard Strain ATCC 25586
Comparative proteomic analysis of Fusobacterium nucleatum clinical strains isolated from brain abscess patients and the standard strain ATCC 25586, using label-free quantification (LFQ) to identify differentially expressed proteins and explore pathogenic mechanisms related to brain abscess.
ORGANISM(S): Fusobacterium Nucleatum Subsp. Nucleatum Atcc 25586 
2026-03-23 | PXD076046 |
ProteomicsSpatially-targeted proteomics of S. aureus abscess formation
Staphylococcus aureus is a major contributor of healthcare-associated infections and able to withstand numerous frequently used antibiotics. In order to develop novel treatment approaches, a deeper understanding of the complex interaction between host and pathogen is required. This is particularly t...
ORGANISM(S): Mus musculus (Mouse) Staphylococcus aureus 
2020-11-30 | PXD019920 | Pride
Kidney Microlesa Lc-ms/ms S. aureus 
GenomicsBrain abscess caused by L. monocytogenes: case study and genome characterization
Brain abscess caused by L. monocytogenes: case study and genome characterization
PRJEB76141 | ENA
GenomicsStreptococcus pyogenes strain:21SPY7071 | isolate:cerebral abscess | cultivar:Pus culture
Streptococcus pyogenes strain:21SPY7071 | isolate:cerebral abscess | cultivar:Pus culture Genome sequencing
PRJNA835576 | ENA
TranscriptomicsNeutrophil-derived IL-1β is sufficient for abscess formation in immunity against Staphylococcus aureus in mice
Neutrophil abscess formation is critical in innate immunity against many pathogens. Here, the mechanism of neutrophil abscess formation was investigated using a mouse model of Staphylococcus aureus cutaneous infection. Gene expression analysis of S. aureus-infected skin revealed that induction of ne...
ORGANISM(S): Mus musculus 
2012-12-05 | GSE36826 | GEO
GenomicsHypervirulent Klebsiella pneumoniae of Sequence Type 1049 causing neck abscess and bacteremia
Hypervirulent Klebsiella pneumoniae of Sequence Type 1049 causing neck abscess and bacteremia
PRJEB38367 | ENA
TranscriptomicsHIF-1 dependent gene expression upon S. aureus infection
HIF-1 is an important transcription factor for immune responses to bacterial infection. We wanted to analyze the HIF-1 dependent gene expression upon S. aureus infection and analyzed the gene expression of HepG2 nt and HepG2 HIF-1-/- cells four hours upon infection using affymetrix human gene 1.0 st...
ORGANISM(S): Homo sapiens 
2013-08-01 | E-GEOD-44943 | biostudies-arrayexpress
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