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TranscriptomicsTranscription profiling of human SCLC cell line set 2
RNA expression analysis was performed to compare patterns to sensitivity to BCL2 inhibitors (ABT-263). Overexpression of the prosurvival Bcl-2 family members (Bcl-2, Bcl-xL and Mcl-1) is commonly associated with tumor maintenance, progression and chemoresistance. We previously reported the discover...
ORGANISM(S): Homo sapiens 
2008-06-19 | E-GEOD-10841 | biostudies-arrayexpress
GenomicsTopical ABT-263 treatment reduces aged skin senescence and improves subsequent wound healing
Topical ABT-263 treatment reduces aged skin senescence and improves subsequent wound healing
PRJNA1130066 | ENA
ProteomicsRemoval of senescent cells reduces the viral load and attenuates pulmonary and systemic inflammation in SARS-CoV-2-infected, aged hamsters
Older age is one of the strongest risk factors for COVID-19 morbidity and mortality. Here, we sought to determine whether age-associated cellular senescence contributes to the severity of COVID-19 by studying the well-established golden hamster model of SARS-CoV-2-driven lung disease. We found that ...
ORGANISM(S): Mesocricetus auratus (Golden hamster) 
2023-07-03 | PXD041973 | Pride
Senolytics Sars-cov-2 Aging Systemic inflammation Proteomics 
TranscriptomicsTopical ABT-263 treatment reduces aged skin senescence and improves subsequent wound healing
Senescent cells accumulate in aging tissues, impairing their ability to undergo repair and regeneration following injury. Previous research has demonstrated that targeting tissue senescence with senolytics can enhance tissue regeneration and repair by selectively eliminating senescent cells in speci...
ORGANISM(S): Mus musculus 
2024-12-17 | GSE271149 | GEO
UnknownCombination treatments with ABT-263 and an immunotoxin produce synergistic killing of ABT-263-resistant small cell lung cancer cell lines.
Not available
S-EPMC3527691 | biostudies-literature
UnknownEffect of ABT-263 on Intestinal Fibrosis in Human Myofibroblasts, Human Intestinal Organoids, and the Mouse Salmonella typhimurium Model.
Not available
S-EPMC9017142 | biostudies-literature
TranscriptomicsAnalysis of lung transcriptome of Mice under normoxia or hypoxia conditions and treated with ABT-263 or its vehicle during 2 days
To explore the role played by senescent cells in mice models of pulmonary hypertension we exposed young C57BL6/j mice to 2 days hypoxia or normoxia and treated with senolytic drug ABT-263 (50mg/kg/day) or its vehicule. We then performed lung gene expression profiling analysis using data obtained fro...
ORGANISM(S): Mus musculus 
2022-12-16 | GSE207324 | GEO
TranscriptomicsAnalysis of lung transcriptome of Mice under normoxia or hypoxia conditions and treated with ABT-263 or its vehicle during 8 days
To explore the role played by senescent cells in mice models of pulmonary hypertension we exposed young C57BL6/j mice to 8 days hypoxia or normoxia and treated with senolytic drug ABT-263 (50mg/kg/day) or its vehicule. We then performed lung gene expression profiling analysis using data obtained fro...
ORGANISM(S): Mus musculus 
2022-12-16 | GSE207256 | GEO
GenomicsAnalysis of lung transcriptome of Mice under normoxia or hypoxia conditions and treated with ABT-263 or its vehicle during 2 days
Analysis of lung transcriptome of Mice under normoxia or hypoxia conditions and treated with ABT-263 or its vehicle during 2 days
PRJNA854817 | ENA
GenomicsAnalysis of lung transcriptome of Mice under normoxia or hypoxia conditions and treated with ABT-263 or its vehicle during 8 days
Analysis of lung transcriptome of Mice under normoxia or hypoxia conditions and treated with ABT-263 or its vehicle during 8 days
PRJNA854388 | ENA
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