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UnknownA common variant mapping to CACNA1A is associated with susceptibility to exfoliation syndrome.
Exfoliation syndrome (XFS) is the most common recognizable cause of open-angle glaucoma worldwide. To better understand the etiology of XFS, we conducted a genome-wide association study (GWAS) of 1,484 cases and 1,188 controls from Japan and followed up the most significant findings in a further 6,9...
S-EPMC4605818 | biostudies-literature
UnknownGenetic association study of exfoliation syndrome identifies a protective rare variant at LOXL1 and five new susceptibility loci.
Exfoliation syndrome (XFS) is the most common known risk factor for secondary glaucoma and a major cause of blindness worldwide. Variants in two genes, LOXL1 and CACNA1A, have previously been associated with XFS. To further elucidate the genetic basis of XFS, we collected a global sample of XFS case...
S-EPMC6685441 | biostudies-literature
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