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TranscriptomicsThe transcription factor Otx2 regulates choroid plexus development and function
The choroid plexuses (ChPs) are the main regulators of cerebrospinal fluid (CSF) composition and thereby also control the composition of a principal source of signaling molecules that is in direct contact with neural stem cells in the developing brain. The regulators of ChP development mediating the...
ORGANISM(S): Mus musculus 
2013-02-05 | E-GEOD-27630 | biostudies-arrayexpress
TranscriptomicsOtx2 binding to Nanog promoter protects embryonal stem cells from corruption of naive pluripotency and is required at morula stage for inner-cell mass differentiation of the epiblast
We have investigated the functional relevance of the transcriptional network controlled by the Otx2 binding activity in ESCs, EpiSCs and in vivo. In particular, to study the Otx2 transcriptional network we first performed Otx2 chromatin immunoprecipitation sequencing (ChIP-seq) experiments in wt ES...
ORGANISM(S): Mus musculus 
2016-06-09 | E-MTAB-3856 | biostudies-arrayexpress
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