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MetabolomicsNAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome (Extracellular UPLC-MS assay)

Metabolic dysfunction is a primary feature of Werner syndrome (WS), a human premature aging disease caused by mutations in the gene encoding the Werner (WRN) DNA helicase. WS patients exhibit severe metabolic phenotypes, but the underlying mechanisms are not understood, and whether the metabolic ...

2019-10-17 | MTBLS1221 | MetaboLights
MetabolomicsNAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome (Intracellular UPLC-MS assay)

Metabolic dysfunction is a primary feature of Werner syndrome (WS), a human premature aging disease caused by mutations in the gene encoding the Werner (WRN) DNA helicase. WS patients exhibit severe metabolic phenotypes, but the underlying mechanisms are not understood, and whether the metabolic ...

2019-10-17 | MTBLS1223 | MetaboLights
MetabolomicsAn overlooked prebiotic: beneficial effect of dietary nucleotide supplementation on gut microbiota and metabolites in senescence-accelerated mouse prone-8 mice
Nucleotides (NTs) are regulatory factors in many biological processes and play important roles in the growth, development, and metabolism of living organisms. We used senescence-accelerated mouse prone-8 (SAMP8) to investigate the effects of NTs on the gut microbiota and metabolites. And the promoti...
2022-03-21 | MTBLS4012 | MetaboLights
ProteomicsPhysiological and proteomic changes in soft wheat seeds during accelerated aging
Wheat (Triticum aestivum L.), one of the most important crops in the world, is a staple food used for making flour, noodles, alcoholic beverages, biofuel and a variety of other products. In wheat, kernel texture and biochemical composition vary with different hardnesses. Previous study of our resear...
ORGANISM(S): Triticum aestivum (Wheat) 
2018-10-08 | PXD009156 | Pride
Tandem mass tag Differentially expressed proteins Wheat Lc-ms/ms 
UnknownEpigenomic signature of accelerated ageing in progeroid Cockayne syndrome.
Not available
S-EPMC10577576 | biostudies-literature
UnknownPhenoage and longitudinal changes on transthoracic echocardiography in Alstrom syndrome: a disease of accelerated ageing?
Not available
S-EPMC10828353 | biostudies-literature
UnknownAssociations between alcohol use and accelerated biological ageing.
Not available
S-EPMC7614236 | biostudies-literature
UnknownTranscriptomic profiling of long- and short-lived mutant mice implicates mitochondrial metabolism in ageing and shows signatures of normal ageing in progeroid mice.
Not available
S-EPMC7895802 | biostudies-literature
UnknownDynamic proteomic changes in soft wheat seeds during accelerated ageing.
Not available
S-EPMC6216954 | biostudies-literature
UnknownThe parasitic worm product ES-62 protects the osteoimmunology axis in a mouse model of obesity-accelerated ageing.
Not available
S-EPMC9465317 | biostudies-literature
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