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TranscriptomicsIntegrated Control of Hepatic Lipogenesis vs. Glucose Production Requires FoxO Transcription Factors
Insulin integrates hepatic glucose and lipid metabolism, directing nutrients to storage as glycogen and triglyceride. In type 2 diabetes, levels of the former are low and the latter are exaggerated, posing a pathophysiologic and therapeutic conundrum. A branching model1 of insulin signaling, with Fo...
ORGANISM(S): Mus musculus 
2014-08-20 | E-GEOD-60527 | biostudies-arrayexpress
TranscriptomicsMetabolic Inflexibility Impairs Insulin Secretion And Results In MODY-like Diabetes In Triple FoxO-deficient Mice
Pancreatic b-cell failure in type 2 diabetes is associated with functional abnormalities of insulin secretion and deficits of b-cell mass. It’s unclear how one begets the other. We have shown that loss of b-cell mass can be ascribed to impaired FoxO1 function in different models of diabetes. Here we...
ORGANISM(S): Mus musculus 
2014-08-20 | E-GEOD-60505 | biostudies-arrayexpress
TranscriptomicsFoxO1 target Gpr17 activates AgRP neurons to regulate food intake.
Hypothalamic neurons expressing Agouti-related peptide (AgRP) are critical for initiating food intake, but druggable biochemical pathways that control this response remain elusive. Thus, genetic ablation of insulin or leptin signaling in AgRP neurons is predicted to reduce satiety but fails to do so...
ORGANISM(S): Mus musculus 
2013-04-09 | E-GEOD-45858 | biostudies-arrayexpress
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