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TranscriptomicsThe trait of MS: Altered transcription regulation of nuclear receptors networks operate in the pre-disease state
Molecular mechanisms that influence susceptibility to multiple sclerosis are poorly understood. We conducted a gene expression study in healthy subjects that subsequently developed the disease. Gene expression profiles (HG U133A and A2, Affymetrix, 22,215 transcripts) of peripheral blood mononuclea...
ORGANISM(S): Homo sapiens 
2010-02-17 | E-GEOD-14895 | biostudies-arrayexpress
TranscriptomicsPrediction of acute multiple sclerosis relapses by transcription levels of peripheral blood cells
Background: The ability to predict the spatial frequency of relapses in multiple sclerosis (MS) would enable treating physicians to decide when to intervene more aggressively and to plan clinical trials more accurately. Methods: In the current study our objective was to determine if subsets of gene...
ORGANISM(S): Homo sapiens 
2009-07-15 | E-GEOD-15245 | biostudies-arrayexpress
TranscriptomicsMyelin-allied gene expression profile of adult neural progenitors shortly after onset of differentiation
Spontaneous neural repair from endogenous neural stem cells (NSCs) occurs in response to central nervous system (CNS) injuries or diseases to only a limited extent from endogenous NSCs niches. Uncovering the mechanisms that control neural repair and can be further manipulated to promote towards olig...
ORGANISM(S): Mus musculus 
2016-06-01 | E-GEOD-76968 | biostudies-arrayexpress
TranscriptomicsPBMC gene expression of early onset of the first demyelinating event of acute optic neuritis
Optic neuritis (ON) is a common manifestation of multiple sclerosis (MS); it appears as the presenting symptom in about 25% of MS patients and occurs in 30–70% of patients with MS during the course of their illness Purpose. To evaluate the molecular pathways that operate in the early phase of acute ...
ORGANISM(S): Homo sapiens 
2014-10-22 | E-GEOD-62584 | biostudies-arrayexpress
UnknownAlemtuzumab improves preexisting disability in active relapsing-remitting MS patients.
Not available
S-EPMC5109953 | biostudies-literature
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