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MetabolomicsLysine acetyltransferase Rv0998 coordinates transcriptional and metabolic adaptation of Mycobacterium tuberculosis to acidic pH

Mycobacterium tuberculosis (Mtb) survives host defences by adapting to host conditions, including acid stress, during infection. A critical survival strategy involves pH homeostasis, mediated by complex signalling systems that regulate metabolic reprogramming and stress responses. While ...

2026-09-03 | MTBLS15171 | MetaboLights
MetabolomicsMultiomic analysis revealed the potential role of rumen microbes in heat stress

Heat stress is an important issue in dairy cattle feeding management affecting summer health and economic efficiency. In recent years, global climate change has led to an increase in atmospheric CO2 content and average daily temperature, making heat stress a major challenge in dairy farming. This...

2022-08-11 | MTBLS5132 | MetaboLights
MetabolomicsAccumulation of the coumarin scopolin under abiotic stress conditions is mediated by the Arabidopsis thaliana THO/TREX complex
Secondary metabolites are involved in the plant stress response. Among these are scopolin and its active form scopoletin, which are coumarin derivatives associated with reactive oxygen species scavenging and pathogen defence. Here we show that in Arabidopsis thaliana, scopolin accumulation can be in...
2018-02-05 | MTBLS389 | MetaboLights
MetabolomicsChronic sleep loss sensitizes Drosophila melanogaster to nitrogen stress

Chronic sleep loss profoundly impacts metabolic health and shortens lifespan, but studies of the mechanisms involved have focused largely on acute sleep deprivation. To identify metabolic consequences of chronically reduced sleep, we conducted unbiased metabolomics on heads of three adult Drosoph...

2023-03-18 | MTBLS3318 | MetaboLights
MetabolomicsMetabolism links nutrient stress and harmful algal bloom formation

Four species of phytoplankton representing important bloom-forming species from three globally important phyla (Bacillariophyta, Haptophyta, and Ochrophyte) were cultured in this study. These species include the cosmopolitan diatom Chaetoceros affinis CCMP159 (isolated from Great South B...

2024-02-28 | MTBLS1807 | MetaboLights
MetabolomicsEffect of heat stress on serum enzyme activity, antioxidant capacity and immune parameter metabolomics datasets in Holstein cows at different growth stages

Global climate change has led to an increase in release of atmospheric CO2 and average daily temperatures, making heat stress a major challenge in dairy farming. The present study aimed to investigate metabolite changes of Holstein cows at different stages. In this experiment, 10 growing heifers,...

2022-08-11 | MTBLS5148 | MetaboLights
MetabolomicsPhysiological, Transcriptomic, and Metabolomic Insights into Ammonia-Nitrogen Stress in the Hepatopancreas of Litopenaeus vannamei Acclimated to Low Salinity
High ammonia nitrogen stress markedly decreases the survival rate of Litopenaeus vannamei under low-salinity conditions. Nevertheless, most available studies have primarily focused on the ammonia nitrogen response of small-sized shrimp under single-stressor exposure or normal seawater salinity. The ...
2026-08-13 | MTBLS14736 | MetaboLights
GenomicsRNA-seq analysis of Lactobacillus at acidic stress
RNA-seq analysis of Lactobacillus at acidic stress
PRJNA419802 | ENA
TranscriptomicsThe pH-sensing receptor OGR1 improves barrier function of CaCo-2 cells and inhibits migration in an acidic environment
OGR1 is a pH-sensing G-protein coupled receptor involved in intestinal homeostasis and inflammation Proton activation of OGR1 increases barrier function in Caco2 cells Microarray profiling was performed on OGR1 stable overexpressing Caco-2 cells during acidic pH shift
ORGANISM(S): Homo sapiens 
2015-08-13 | E-GEOD-60294 | biostudies-arrayexpress
GenomicsTranscriptional profiling of M. intracellulare under acidic and oxidative stress conditions
Transcriptional profiling of M. intracellulare under acidic and oxidative stress conditions
PRJNA1022021 | ENA
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