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TranscriptomicsRibosome stalling induced by mutation of a CNS-specific tRNA causes neurodegeneration
In higher eukaryotes, the large numbers of nuclear-encoded tRNA genes partially ensure the robustness of cytoplasmic protein translation. Here we discover that a loss-of-function in n-Tr20, a member of the nuclear-encoded tRNA Arg UCU family that is expressed specifically in the central nervous syst...
ORGANISM(S): Mus musculus 
2014-07-28 | E-GEOD-56127 | biostudies-arrayexpress
TranscriptomicsExamination of gene expression in cerebellum of mouse strains B6J, B6J-nmf205-/-, B6J-Gcn2-/- and B6J-nmf205-/-;Gcn2-/-.
Ribosome stalling during translation has recently been shown to cause neurodegeneration, yet the signaling pathways triggered by stalled elongation complexes are unknown. To investigate these pathways we analyzed the brain of B6J-nmf205-/- mice in which neuronal elongation complexes are stalled at...
ORGANISM(S): Mus musculus 
2016-06-15 | E-GEOD-79929 | biostudies-arrayexpress
TranscriptomicsExamination of gene expression in cerebellum and hippocampus for mouse C57BL/6J WT and nmf205-/-
Ribosome stalling during translation has recently been shown to cause neurodegeneration, yet the signaling pathways triggered by stalled elongation complexes are unknown. To investigate these pathways we analyzed the brain of B6J-nmf205-/- mice in which neuronal elongation complexes are stall...
ORGANISM(S): Mus musculus 
2016-06-15 | E-GEOD-79926 | biostudies-arrayexpress
UnknownStructures, processes and outcomes between first referral and referral hospitals in low-income and middle-income countries: a secondary preplanned analysis of the FALCON and ChEETAh randomised trials.
Not available
S-EPMC11552540 | biostudies-literature
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