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MetabolomicsTranscriptional differentiation of Trypanosoma brucei during in vitro acquisition of resistance to acoziborole

Subspecies of the protozoan parasite Trypanosoma brucei are the causative agents of Human African Trypanosomiasis (HAT), a debilitating neglected tropical disease prevalent across sub-Saharan Africa. HAT case numbers have steadily decreased since the start of the century, and sustainable...

2021-11-02 | MTBLS2559 | MetaboLights
GenomicsOxaboroles target trypanosome CPSF3 - Acoziborole screen
Oxaboroles target trypanosome CPSF3 - Acoziborole screen
PRJEB25884 | ENA
TranscriptomicsTranscriptional differentiation of Trypanosoma brucei during in vitro acquisition of resistance to acoziborole
Purpose: Acoziborole is a recently developed benzoxaborole class compound, currently in clinical trials, for stage 1 and stage 2 treatment of Human African Trypanosomiasis. Recent studies have made significant progress in determining the molecular mode of action of acoziborole. However, less is know...
ORGANISM(S): Trypanosoma brucei brucei 
2021-03-07 | GSE168394 | GEO
GenomicsTranscriptional differentiation of Trypanosoma brucei during in vitro acquisition of resistance to acoziborole
Transcriptional differentiation of Trypanosoma brucei during in vitro acquisition of resistance to acoziborole
PRJNA707209 | ENA
UnknownTranscriptional differentiation of Trypanosoma brucei during in vitro acquisition of resistance to acoziborole.
Not available
S-EPMC8648117 | biostudies-literature
UnknownHypothesis-generating proteome perturbation to identify NEU-4438 and acoziborole modes of action in the African Trypanosome.
Not available
S-EPMC9593816 | biostudies-literature
Genomics
Acoziborole resistance associated mutations in trypanosome CPSF3
PRJNA1365812 | ENA
UnknownEfficacy and safety of acoziborole in patients with human African trypanosomiasis caused by Trypanosoma brucei gambiense: a multicentre, open-label, single-arm, phase 2/3 trial.
Not available
S-EPMC10033454 | biostudies-literature
UnknownTrypanosome spliced leader RNA for diagnosis of acoziborole treatment outcome in gambiense human African trypanosomiasis: A longitudinal follow-up study.
Not available
S-EPMC9700268 | biostudies-literature
UnknownDetermination of the Optimal Single Dose Treatment for Acoziborole, a Novel Drug for the Treatment of Human African Trypanosomiasis: First-in-Human Study.
Not available
S-EPMC10042906 | biostudies-literature
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