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MetabolomicsChlorogenic acid improves obesity by regulating serum metabolites

Obesity, a globally prevalent chronic metabolic disorder, has been increasingly confirmed to involve gut microbiota as a pivotal regulator in its pathogenesis. Chlorogenic acid (CGA) has been reported to exert beneficial effects on lipid metabolism regulation and obesity amelioration. However, t...

2025-09-18 | MTBLS13009 | MetaboLights
MetabolomicsMetabolomic fingerprint of severe obesity is dynamically affected by bariatric surgery in a procedure-dependent manner
Obesity is associated with multiple diseases. Bariatric surgery is the most effective therapy for severe obesity that can reduce body weight and obesity-associated morbidity. The metabolic alterations associated with obesity and respective changes after bariatric surgery are incompletely understood....
2017-02-10 | MTBLS242 | MetaboLights
MetabolomicsAuricularia auricula polysaccharides reduce obesity in mice through gut commensal Papillibacter cinnamivorans
Auricularia auricula is a well-known traditional edible and medicial fungus with high nutritional and pharmacological values, as well as metabolic and immunoregulatory properties. However, the exact mechanisms underlying the effects of Auricularia auricula polysaccharides (AAP) on obesity and relate...
2022-09-16 | MTBLS4469 | MetaboLights
MetabolomicsMetabolomic Profile of Diet-Induced Obesity Mice in Response to Human and Small Humanin-like Peptide 2 Treatment

INTRODUCTION: The mitochondrial-derived peptides (MDPs) are a novel group of natural occurring peptides that have important signaling functions and biological activity. Both humanin and small-humanin-like peptide 2 (SHLP2) have been reported to act as insulin sensitizers and modu...

2019-06-21 | MTBLS159 | MetaboLights
MetabolomicsDefined microbiota modulates host metabolome and skeletal adaptation to diet-induced obesity

Background

The gut microbiota is increasingly recognized as a regulator of host metabolism and bone physiology. However, how microbial colonization integrates systemic metabolic cues with skeletal remodeling under metabolic stress remains unclear.

Results

We used germ-free (GF) ...

2025-11-25 | MTBLS13384 | MetaboLights
TranscriptomicsTranscription profiling of fat biopsies from monozygotic twins discordant for body mass index to elucidate the effects of acquired obesity
Elucidating the effects of acquired obesity by comparison of fat biopsies from monozygotic twins discordant for BMI.
ORGANISM(S): Homo sapiens 
2008-02-15 | E-MEXP-1425 | biostudies-arrayexpress
MetabolomicsPuerarin Combined with Hericium Erinaceus Insoluble Dietary Fiber Alleviate Obesity Induced by High-fat Diet Through Regulating the Glycerophospholipid Metabolism Pathway Influenced by Gut Microbiota
The combination of HEIDF and Pue holds significant importance in the context of obesity. This synergistic effect not only aids in weight management but may also enhance metabolic health through various mechanisms, including increased satiety and promotion of fat oxidation. Therefore, incorporating t...
2025-02-17 | MTBLS12195 | MetaboLights
MetabolomicsTreatment of lean and diet-induced obesity (DIO) mice with a novel stable obestatin analogue alters plasma metabolite levels as detected by untargeted LC-MS metabolomics
Introduction: Obestatin is a controversial gastrointestinal peptide purported to have metabolic actions. Objectives: This study investigated whether treatment with a stable obestatin analogue (PEG-OB(Cys10, Cys13) changed plasma metabolite levels firstly in lean and subsequently in diet-induced obes...
2017-07-25 | MTBLS334 | MetaboLights
MetabolomicsFaecalibaculum rodentium as a key player in combating maternal obesity-induced labor disorders

The global rise in maternal obesity increases the risk of adverse maternal and neonatal outcomes. This study demonstrates that both long- (12 weeks) and short-term (gestational) exposure to a high-fat diet (HFD) induces uterine labor disorders, elevates stillbirth rates, and alters gut microbiota...

2025-08-22 | MTBLS12877 | MetaboLights
TranscriptomicsJuvenile obesity in Ossabaw swine produces artery-specific transcriptional changes
We adopted a transcriptome-wide microarray analysis approach to determine the extent to which vascular gene expression is altered as a result of juvenile obesity and identify obesity-responsive mRNAs. We examined transcriptional profiles in the left anterior descending coronary artery (LAD), perivas...
ORGANISM(S): Sus scrofa 
2013-05-29 | E-GEOD-41636 | biostudies-arrayexpress
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