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TranscriptomicsActivation-induced cytidine deaminase induces reproducible DNA breaks at many non-Ig loci in activated B cells
After immunization or infection, activation-induced cytidine deaminase (AID) initiates diversification of immunoglobulin (Ig) genes in B cells, introducing mutations within the antigen binding V regions (somatic hypermutation, SHM) and double-strand DNA breaks (DSBs) into switch (S) regions, leading...
ORGANISM(S): Mus musculus 
2011-01-21 | E-GEOD-24827 | biostudies-arrayexpress
GenomicsGenome wide localization of Activation induced cytidine deaminase (AID), Spt5, and RNA Polymerase II (PolII) in mouse
Activation induced cytidine deaminase (AID) initiates antibody gene diversification by creating U:G mismatches. However, AID is not specific for antibody genes. Off-target lesions can activate oncogenes or cause chromosome translocations. Despite its importance in these key transactions little is kn...
ORGANISM(S): Mus musculus 
2010-10-05 | E-GEOD-24178 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human BCR-ABL1-transformed acute lymphoblastic leukemia cells reveals Activation-induced cytidine deaminase acts as a mutator
The Philadelphia chromosome (Ph) encoding the oncogenic BCR-ABL1 kinase defines a subset of ALL with a particularly unfavorable prognosis. Acute lymphoblastic leukemia (ALL) cells are derived from B cell precursors in most cases and typically carry rearranged immunglobulin heavy chain (IGH) variable...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-7182 | biostudies-arrayexpress
TranscriptomicsInvestigating epigenetic effects of activation-induced deaminase in chronic lymphocytic leukemia
Activation induced deaminase (AID) has two distinct and well defined roles, both relying on its deoxycytidine (dC) deaminating function: one as a DNA mutator and another in DNA demethylation. In chronic lymphocytic leukemia (CLL), AID was previously shown to be an independent negative prognostic fac...
ORGANISM(S): Homo sapiens 
2018-11-29 | E-MTAB-7431 | biostudies-arrayexpress
TranscriptomicsEpigenetic targeting of activation-induced cytidine deaminase
Precisely how AID is recruited to these off-target sites is not entirely understood. To gain further insight into how AID selects its targets we compared AID-mediated translocations in two different cell types, B cells and mouse embryonic fibroblasts (MEFs). AID targets a distinct set of hotspots in...
ORGANISM(S): Mus musculus 
2015-01-30 | E-GEOD-61523 | biostudies-arrayexpress
GenomicsExpression of Activation Induced Cytidine Deaminase and Risk of Transformation in Follicular Lymphoma
Expression of Activation Induced Cytidine Deaminase and Risk of Transformation in Follicular Lymphoma
PRJNA815873 | ENA
GenomicsExpression of Activation Induced Cytidine Deaminase and Risk of Transformation in Follicular Lymphoma
Expression of Activation Induced Cytidine Deaminase and Risk of Transformation in Follicular Lymphoma
PRJNA815874 | ENA
GenomicsActivation Induced Deaminase defines a mature Burkitt-like lymphoma in the mouse
Activation Induced Deaminase defines a mature Burkitt-like lymphoma in the mouse
PRJNA999298 | ENA
UnknownPhosphorylation directly regulates the intrinsic DNA cytidine deaminase activity of activation-induced deaminase and APOBEC3G protein.
Not available
S-EPMC3143621 | biostudies-literature
GenomicsActivation-induced cytidine deaminase induces DNA demethylation and expression of Ninjurin-2 gene
Activation-induced cytidine deaminase induces DNA demethylation and expression of Ninjurin-2 gene
PRJNA1129578 | ENA
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