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UnknownStructural snapshots of actively translating human ribosomes.
Not available
S-EPMC4432480 | biostudies-literature
TranscriptomicsActively translating transcriptome (Ribotag) profiling of mouse retinal endothelial cells during postnatal development
Angiogenesis, a process mediating the expansion of vascular beds in many physiological and pathological settings, requires dynamic changes in endothelial cell (EC) behavior. The molecular mechanisms governing EC activity during different phases of vascular growth, remodeling, maturation, and quiesce...
ORGANISM(S): Mus musculus 
2020-08-28 | E-MTAB-5087 | biostudies-arrayexpress
UnknownReal-time observation of signal recognition particle binding to actively translating ribosomes.
Not available
S-EPMC4213662 | biostudies-literature
ProteomicsIn vivo murine brain protein synthesis uncover the molecular physiological process in brain
Identification of proteins that are synthesised de novo in response to specific microenvironmental cues is critical for understanding the molecular mechanisms, which underpin vital physiological processes and pathologies. Here, we report that a brief period of pulsed SILAM (Stable Isotope Labeling o...
ORGANISM(S): Mus musculus (Mouse) 
2020-06-23 | PXD013502 | Pride
Pulsed silam Psivom Brain physiology Actively translating protein 
GenomicsA Single-copy Knock In Translating Ribosome ImmunoPrecipitation (SKI TRIP) tool kit for tissue specific profiling of actively translated mRNAs in C. elegans.
A Single-copy Knock In Translating Ribosome ImmunoPrecipitation (SKI TRIP) tool kit for tissue specific profiling of actively translated mRNAs in C. elegans.
PRJNA801467 | ENA
TranscriptomicsA Single-copy Knock In Translating Ribosome ImmunoPrecipitation (SKI TRIP) tool kit for tissue specific profiling of actively translated mRNAs in C. elegans.
Translating Ribosome Affinity Purification (TRAP) methods have emerged as a powerful approach to profile actively translated transcripts in specific cell and tissue types. Epitope tagged ribosomal subunits are expressed in defined cell populations and used to pull down ribosomes and their associated...
ORGANISM(S): Caenorhabditis elegans 
2022-01-31 | GSE195601 | GEO
TranscriptomicsThe Small Molecule ISRIB Reverses the Effects of eIF2α Phosphorylation on Translation and Stress Granule Assembly
We recently identified ISRIB as a potent inhibitor of the integrated stress response (ISR). ISRIB renders cells resistant to the effects of eIF2α phosphorylation and enhances long-term memory in rodents (10.7554/eLife.00498). Here we show by genome-wide in vivo ribosome profiling that translation o...
ORGANISM(S): Homo sapiens 
2015-02-27 | E-GEOD-65778 | biostudies-arrayexpress
UnknownA single-copy knockin translating ribosome immunoprecipitation toolkit for tissue-specific profiling of actively translated mRNAs in C. elegans.
Not available
S-EPMC10088236 | biostudies-literature
UnknownStructure of the actively translating plant 80S ribosome at 2.2 A resolution.
Not available
S-EPMC10281867 | biostudies-literature
TranscriptomicsTranscriptome-wide identification of LARP4B binding sites in HEK293 cells
mRNAs are key molecules in gene expression and subject to diverse regulatory events. Regulation is accomplished by distinct sets of trans-acting factors that interact with mRNAs and form defined mRNA-protein complexes (mRNPs). The resulting “mRNP code” determines the fate of any given mRNA and thus ...
ORGANISM(S): Homo sapiens 
2015-05-26 | E-GEOD-69169 | biostudies-arrayexpress
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