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MetabolomicsL-fucose and fucoidan alleviate high-salt diet-promoted acute inflammation

Excessive salt intake is a widespread health issue observed in almost every country around the world. A high salt diet (HSD) has a strong correlation with numerous diseases, including hypertension, chronic kidney disease and autoimmune disorders. However, the mechanisms underlying HSD-promotion o...

2024-02-21 | MTBLS9134 | MetaboLights
MetabolomicsImmunomodulatory activity of hyaluronidase is associated with metabolic adaptations during acute inflammation
Not available
ORGANISM(S): Mus musculus 
ST001255 | MetabolomicsWorkbench
MetabolomicsExplore changes of riboflavin metabolism in acute pancreatitis

Gut barrier dysfunction is critical in the pathogenesis of acute pancreatitis (AP), yet the underlying mechanisms remain unclear. Mucin 2 (MUC2), the primary component of the intestinal mucus layer, is essential for gut homeostasis and microbial eubiosis. This study aimed to elucidate the protec...

2025-09-11 | MTBLS12981 | MetaboLights
MetabolomicsAlterations in gut microbiota and metabolomic profiles in acute stroke: insights into brain–gut axis dysregulation

Acute stroke (AS) is a major public health issue globally, exhibiting high morbidity, disability rate, and mortality. Emerging research has demonstrated the critical roles of gut microbiota and its metabolites in pathogenesis, recovery, and prognosis of AS. In this study, we investigated alterati...

2025-08-06 | MTBLS12822 | MetaboLights
MetabolomicsDysregulation of lipid metabolism and pathological inflammation in patients with COVID-19
In recent months, Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread throughout the world. COVID-19 patients show mild, moderate or severe symptoms with the latter ones requiring access to specialized intensive care. SARS-CoV-2 infec...
2023-02-01 | MTBLS6844 | MetaboLights
TranscriptomicsHuman dendritic cell subsets in acute skin inflammation
An unexpected BDCA-2+CD123+CD1a+ dendritic cell (DC) subset comprised a major DC population in acute human sterile skin inflammation. Single-cell RNAseq showed these to be activated DC able to express markers normally associated with plasmacytoid DC, prompting a re-evaluation of previous studies.
ORGANISM(S): Homo sapiens 
2019-12-01 | E-MTAB-8498 | biostudies-arrayexpress
MetabolomicsComparison of intestinal microbes and metabolites in active VKH versus acute anterior uveitis associated with ankylosing spondylitis

BACKGROUND: It has been reported that the gut microbiome is involved in the pathogenesis of uveitis, but the specific pathogenic microbes and metabolites in different types of uveitis are still unclear.

METHODS:&...

2023-12-12 | MTBLS7936 | MetaboLights
MetabolomicsMoxibustion Inhibits Inflammation in Monosodium Urate Crystal-induced Gouty Arthritis Model Rats through Metabolomic Regulation

Background: Moxibustion is a form of therapy that to warm the acupoints located skin by using dried mugwort leaves. It is widely used to treat gouty arthritis (GA). However, the mechanism of moxibustion on improving GA has not been fully revealed. In this study, we explore the mechanism of moxibu...

2025-03-03 | MTBLS12225 | MetaboLights
MetabolomicsDistinct lipid signatures are identified in the plasma of rats with chronic inflammation induced by estradiol benzoate and sex hormones

INTRODUCTION: Prostatitis is likely to occur in younger or middle-aged men, while prostate cancer is likely to occur in older men. Although amino acids and lipids as biomarkers of prostate cancer have been examined using prostate cancer cell lines/tissues, no previous studies hav...

2020-11-04 | MTBLS2028 | MetaboLights
TranscriptomicsImmune cell-specific Cyp11a1 deletion impairs inflammation resolution following LPS-induced acute lung injury in mice
Bulk RNA sequencing was performed on lung tissue from control and immune cell-specific Cyp11a1 conditional knockout (Cyp11a1fl/fl;Vav1Cre) mice following lipopolysaccharide (LPS)-induced acute lung injury. The experiment was designed to characterise genome-wide transcriptional changes associated wit...
ORGANISM(S): Mus musculus 
2026-09-15 | E-MTAB-17666 | biostudies-arrayexpress
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