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MetabolomicsParallel single-cell metabolic analysis and extracellular vesicle profiling reveal vulnerabilities with prognostic significance in acute myeloid leukemia (Lipidomic analysis on extracellular vesicles)

Acute myeloid leukemia (AML) is an aggressive disease with a high relapse rate. In this study, we map the metabolic profile of CD34+(CD38low/-) AML cells and the extracellular vesicle signatures in circulation from AML patients at diagnosis. CD34+ AML cells display high antioxidant glutathione le...

2024-12-04 | MTBLS11523 | MetaboLights
MetabolomicsParallel single-cell metabolic analysis and extracellular vesicle profiling reveal vulnerabilities with prognostic significance in acute myeloid leukemia (Metabolomic analysis on extracellular vesicles)

Acute myeloid leukemia (AML) is an aggressive disease with a high relapse rate. In this study, we map the metabolic profile of CD34+(CD38low/-) AML cells and the extracellular vesicle signatures in circulation from AML patients at diagnosis. CD34+ AML cells display high antioxidant glutathione le...

2024-12-04 | MTBLS11746 | MetaboLights
TranscriptomicsPrognostic gene signature for AML
Acute myeloid leukemia (AML) is a heterogeneous disease in respect of molecular aberrations and prognosis. We used gene expression profiling of 562 patients treated in the German AMLCG 1999 trial to develop a gene signature that predicts survival in AML. Analysis of 562 samples (140 HGU-133plus2; 42...
ORGANISM(S): Homo sapiens 
2013-02-07 | E-GEOD-37642 | biostudies-arrayexpress
TranscriptomicsSingle cell long read genotyping of transcripts reveals discrete mechanisms of clonal evolution in post-MPN AML
Myeloproliferative neoplasm (MPN) or post-MPN acute myeloid leukemia patient bone marrow aspirates were sorted for CD34+ hematopoietic stem and progenitor cells (HSPCs), followed by 10x 3' single cell RNA sequencing and long read sequencing to study the consequences of mutation combination on HSPCs.
ORGANISM(S): Homo sapiens 
2026-06-25 | E-MTAB-15981 | biostudies-arrayexpress
TranscriptomicsDNA copy number analysis from mice with radiation-induced acute myeloid leukemia
Certain mouse strains such as CBA, C3H and RFM, have high incidence of radiation-induced acute myeloid leukemia (AML). The data in this serie was generated by using spleen DNA from CBA mice which were irraidated with either gamma-rays or heavy ion (HZE) particles. Spleen DNA with radiation-induced A...
ORGANISM(S): Mus musculus 
2012-10-05 | E-GEOD-37233 | biostudies-arrayexpress
TranscriptomicsComparative genomic hybridization by array of blasts and normal cells from acute myeloid leukemia patients to study germinal copy number variants as potential disease risk factors
Except for the well-known association with Down syndrome, there is little information on the genetic factors predisposing to acute myeloid leukemia. Germinal gene copy-number variations may represent risk factors for the disease. To identify copy number variants present in both normal and leukemic ...
ORGANISM(S): Homo sapiens 
2015-10-01 | E-MTAB-2609 | biostudies-arrayexpress
TranscriptomicsMolecular characterization of AML with ins(21;8)(q22;q22q22) reveals similarity to t(8;21) AML
In acute myeloid leukemia (AML) non-random clonal chromosome aberrations are detectable in ~55% of adults with AML. Translocation t(8;21)(q22;q22) resulting in the 5'RUNX1/3'RUNX1T1 fusion gene occurs in ~8% of acute myeloid leukemia (AML) cases. Also, insertions ins(8;21) and ins(21;8) have been de...
ORGANISM(S): Homo sapiens 
2010-10-26 | E-GEOD-24384 | biostudies-arrayexpress
TranscriptomicsFLT3 gene-expression signature in normal karyotype AML
Acute myeloid leukemia with normal karyotype (NK-AML) represents a cytogenetic grouping with intermediate prognosis but substantial molecular and clinical heterogeneity. Within this subgroup, presence of FLT3 (FMS-like tyrosine kinase 3) internal tandem duplication (ITD) mutation predicts less favo...
ORGANISM(S): Homo sapiens 
2008-02-27 | E-GEOD-8043 | biostudies-arrayexpress
TranscriptomicsInhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia [Illumina HumanHT-12 gene expression array]
All-trans-retinoic acid (ATRA) has been successfully used in therapy of acute promyelocytic leukemia (APL), a cytogenetically distinct subtype of acute myeloid leukemia (AML) but the response of non-APL AML cases to ATRA-based treatment has been poor. Here we show that, via epigenetic reprogramming,...
ORGANISM(S): Homo sapiens 
2012-03-14 | E-GEOD-34672 | biostudies-arrayexpress
TranscriptomicsAltered Hematopoietic Cell Gene Expression Precedes Development of Therapy-Related Myelodysplasia and Identifies Patients at Risk
Therapy-related myelodysplasia or acute myeloid leukemia (t-MDS/AML) is a lethal complication of cancer treatment. Although t-MDS/AML development is associated with known genotoxic exposures, its pathogenesis is not well understood and methods to predict risk of development of t-MDS/AML in individua...
ORGANISM(S): Homo sapiens 
2011-12-12 | E-GEOD-23025 | biostudies-arrayexpress
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