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MetabolomicsMultiple acyl-coA dehydrogenase deficiency kills Mycobacterium tuberculosis in vitro and during infection

The human pathogen Mycobacterium tuberculosis (Mtb) devotes a significant fraction of its genome to fatty acid metabolism. Although Mtb depends on host fatty acids as a carbon source, fatty acid b-oxidation is mediated by genetically redundant enzymes, which has hampered the development of antitu...

2021-09-29 | MTBLS2374 | MetaboLights
MetabolomicsMetabolic characterization of the natural progression of chronic hepatitis B (Biogenic amine and Acyl-carnitine assays)
Background: Worldwide, over 350 million people are chronically infected with the hepatitis B virus (HBV) and are at increased risk of developing progressive liver diseases. The confinement of HBV replication to the liver, which also acts as the central hub for metabolic and nutritional regulation, e...
2016-06-06 | MTBLS280 | MetaboLights
MetabolomicsFatty acid transport protein 4 is required for incorporation of saturated ultralong-chain fatty acids into epidermal ceramides and monoacylglycerols
Fatty acid transport protein 4 (FATP4) is an acyl-CoA synthetase that is required for normal permeability barrier in mammalian skin. FATP4 (SLC27A4) mutations cause ichthyosis prematurity syndrome, a nonlethal disorder. In contrast, Fatp4-/- mice die neonatally from a defective barrier. H...
2021-07-15 | MTBLS1138 | MetaboLights
TranscriptomicsKnockout of the Acyl CoA binding protein (ACBP) in mice - expression profile from the liver of 21 days old ACBP-/- and +/+ mice.
The ACBP knockout were created by targeted disruption of the gene in mice. The expression profiling was performed on liver tissue from ACBP-/- (KO) and +/+ (WT) mice at the age of 21 days, which in our study is the time immediately before weaning. The mice used for this experiment were taken directl...
ORGANISM(S): Mus musculus 
2010-11-26 | E-GEOD-24451 | biostudies-arrayexpress
UnknownMalonyl-CoA: acyl carrier protein transacylase from Helicobacter pylori: Crystal structure and its interaction with acyl carrier protein.
Not available
S-EPMC2206670 | biostudies-literature
UnknownAcyl carrier protein structural classification and normal mode analysis.
Not available
S-EPMC3403463 | biostudies-literature
UnknownTrapping of the Enoyl-Acyl Carrier Protein Reductase-Acyl Carrier Protein Interaction.
Not available
S-EPMC4988885 | biostudies-literature
UnknownResin supported acyl carrier protein labeling strategies.
Not available
S-EPMC4012645 | biostudies-literature
MetabolomicsAkkermansia muciniphila secretes a glucagon-like peptide-1-inducing protein that improves glucose homeostasis and ameliorates metabolic disease
The gut microbiome is a key factor regulating energy-metabolism, glucose tolerance and the immune system. Akkermansia muciniphila has been identified as being beneficial gut bacterium for metabolic diseases, including obesity and type 2 diabetes (T2D); however, the molecular mechanisms involved in h...
2021-01-13 | MTBLS1824 | MetaboLights
UnknownChasing acyl carrier protein through a catalytic cycle of lipid A production.
Not available
S-EPMC3947097 | biostudies-literature
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