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MetabolomicsSterol-O acyltransferase inhibition ameliorates high-fat diet-induced renal fibrosis and tertiary lymphoid tissue maturation after ischemic reperfusion injury (Mice+diet analysis)

Metabolic syndrome is a growing global health problem and is strongly associated with the development of chronic kidney disease (CKD). Recently, the prevalence of CKD has been increasing worldwide, particularly among the older adults. We previously demonstrated that aged kidneys are prone to deve...

2022-12-05 | MTBLS4994 | MetaboLights
MetabolomicsSterol-O acyltransferase inhibition ameliorates high-fat diet-induced renal fibrosis and tertiary lymphoid tissue maturation after ischemic reperfusion injury (Mice+injury analysis)

Metabolic syndrome is a growing global health problem and is strongly associated with the development of chronic kidney disease (CKD). Recently, the prevalence of CKD has been increasing worldwide, particularly among the older adults. We previously demonstrated that aged kidneys are prone to deve...

2022-12-05 | MTBLS4988 | MetaboLights
TranscriptomicsInhibiting Monoacylglycerol Acyltransferase 1 Ameliorates Hepatic Metabolic Abnormalities, but not Inflammation and Injury in Mice
Abnormalities in hepatic lipid metabolism are believed to play a critical role in the etiology of nonalcoholic steatohepatitis (NASH). Monoacylglycerol acyltransferase (MGAT) enzymes convert monoacylglycerol to diacylglycerol, which is the penultimate step in one pathway for triacylglycerol (TAG) sy...
ORGANISM(S): Mus musculus 
2014-11-05 | E-GEOD-60349 | biostudies-arrayexpress
TranscriptomicsCarbon Redistribution from Surface Lipids into Triacylglycerols in Leaves of Arabidopsis by Introducing a Chlamydomonas Diacylglycerol Acyltransferase 2
Plants and microalgae have the ability to harness sunlight into energy dense molecules such as triacylglycerols (TAGs). TAGs hold great importance for human and animal nutrition, and are also a source for renewable energy. Acyl-CoA-dependent TAG synthesis by diacylglycerol acyltransferases (DGATs) i...
ORGANISM(S): Arabidopsis thaliana 
2014-06-16 | E-GEOD-38898 | biostudies-arrayexpress
TranscriptomicsA grapevine anthocyanin acyltransferase, transcriptionally regulated by VvMYBA, can produce most acylated anthocyanins present in grape skins
Anthocyanins are flavonoid compounds responsible for red/purple colours in the leaves, fruit and flowers of many plant species. They are produced through a multistep pathway which is controlled by MYB transcription factors. VvMYBA1 and VvMYBA2 activate anthocyanin biosynthesis in grapevine (Vitis vi...
ORGANISM(S): Vitis vinifera 
2015-10-16 | E-GEOD-56915 | biostudies-arrayexpress
Genomicsacyltransferase brachypodium-arabidopsis-Impact of Brachypodium acyl-transferases
acyltransferase brachypodium-arabidopsis-Impact of Brachypodium acyl-transferases
PRJNA491727 | ENA
ProteomicsCholesteryl α-D-glucoside 6-acyltransferase enhances the adhesion of Helicobacter pylori to gastric epithelium
Cellular locations of (Cholesteryl α-D-glucoside 6-acyltransferase) CGAT To study the cellular location of CGAT, based on our pervious experiments, the CGAT activity was observed in the outer membrane vesicles (OMVs), rather than in the culture medium, suggesting that CGAT resided in the outer mem...
ORGANISM(S): Helicobacter pylori 26695 
2020-03-19 | PXD017518 | Pride
Helicobacter pylori Cholesteryl glucoside Acyltransferase Lipid raft Outer membrane vesicle Integrin 
ProteomicsSelection of the length of fatty acyl chain and of the acylation site by the acyltransferase governs activation of RTX toxins
Numerous proteins synthesized in cells ranging from bacteria to humans have to be posttranslationally acylated to become biologically active. Bacterial Repeats in ToXin (RTX) cytolysins form a prominent group of proteins that are synthesized as inactive protoxins and undergo a posttranslational acyl...
ORGANISM(S): Escherichia coli Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251) 
2020-05-20 | PXD018859 | Pride
Fatty acyl Rtx toxin Acyltransferase Acylation Cytotoxicity 
GenomicsZebrafish are resilient to the loss of major diacylglycerol acyltransferase enzymes
Zebrafish are resilient to the loss of major diacylglycerol acyltransferase enzymes
PRJNA1171015 | ENA
ProteomicsAn Acquired Acyltransferase Promotes Klebsiella pneumoniae ST258 Respiratory Infection
Klebsiella pneumoniae ST258 are human pathogens associated with poor outcomes in patients worldwide. We identified a member of the acyltransferase superfamily 3 (atf3), enriched within the ST258 clade, that provides a major competitive advantage for the proliferation of this group of organisms in vi...
ORGANISM(S): Klebsiella Pneumoniae 
2021-04-12 | MSV000087181 | MassIVE
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