Sort   by:  
 Page size 
ProteomicsAn integrative proteotranscriptomics approach reveals new ADAM9 substrates and downstream pathways
An integrative proteotranscriptomics approach to uncover the transcriptional and post-transcriptional targets of the disintegrin metalloproteinase ADAM9, a sheddase that has been implicated in solid tumors, autoimmunity, inflammatory diseases and COVID-19. This systematic approach revealed signaling...
ORGANISM(S): Homo sapiens (Human) 
2026-04-13 | PXD059109 | Pride
Multiomics Metalloproteinase Proteotranscriptomics Integration Adam9 Target identification 
GenomicsADAM9 deficiency mediates KRAS related pathways in pancreatic cancer cells
ADAM9 deficiency mediates KRAS related pathways in pancreatic cancer cells
PRJNA1028989 | ENA
GenomicsInhibition of ADAM9 mediates KRAS-related pathways in pancreatic cancer cells
Inhibition of ADAM9 mediates KRAS-related pathways in pancreatic cancer cells
PRJNA1030022 | ENA
GenomicsUbiquitin-specific peptidase 39 promotes human glioma cells migration and invasion by facilitating ADAM9 mRNA maturation
Ubiquitin-specific peptidase 39 promotes human glioma cells migration and invasion by facilitating ADAM9 mRNA maturation
PRJNA670655 | ENA
TranscriptomicsExpression data from cultured primary mouse dermal fibroblasts
In previous investigations, we detected that growth of melanoma cells in mice depleted for adam9 is enhanced. This resulted from molecular alterations in stromal cells cross-communicating to tumor cells and from constitutively altered expression of some molecules, e.g., TIMP1 in stromal fibroblasts ...
ORGANISM(S): Mus musculus 
2014-03-28 | E-GEOD-56304 | biostudies-arrayexpress
UnknownADAM9 contributes to vascular invasion in pancreatic ductal adenocarcinoma.
Not available
S-EPMC6360373 | biostudies-literature
TranscriptomicsADAM9 deficiency mediates KRAS related pathways in pancreatic cancer cells
Kirsten rat sarcoma virus (KRAS) signaling drives pancreatic ductal adenocarcinoma (PDAC) malignancy, which is an unmet clinical need. Here we identify a disintegrin and metalloproteinase domain 9 (ADAM9) as a modulator of PDAC progression via stabilization of wild-type and mutant KRAS proteins. Mec...
ORGANISM(S): Mus musculus 
2023-12-11 | GSE245560 | GEO
TranscriptomicsInhibition of ADAM9 mediates KRAS-related pathways in pancreatic cancer cells
Kirsten rat sarcoma virus (KRAS) signaling drives pancreatic ductal adenocarcinoma (PDAC) malignancy, which is an unmet clinical need. Here we identify a disintegrin and metalloproteinase domain 9 (ADAM9) as a modulator of PDAC progression via stabilization of wild-type and mutant KRAS proteins. Mec...
ORGANISM(S): Homo sapiens 
2023-12-11 | GSE245819 | GEO
TranscriptomicsUbiquitin-specific peptidase 39 promotes human glioma cells migration and invasion by facilitating ADAM9 mRNA maturation
Glioma is characterized by high migration and invasion, and the relative molecular mechanism is still poor. Accumulating studies demonstrated that ubiquitin specific protease 39 (USP39) played an oncogenic role in several cancers. Here, we investigate USP39 expression and function in human glioma. O...
ORGANISM(S): Homo sapiens 
2020-10-23 | GSE159823 | GEO
UnknownAnalysis of ADAM9 regulation and function in vestibular schwannoma primary cells.
Not available
S-EPMC7659081 | biostudies-literature
Sort   by:  
 Page size