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TranscriptomicsExpression data from 7 Human Melanomas
Melanocytes within benign human nevi are the paradigm for tumor suppressive senescent cells in a pre-malignant neoplasm. These cells typically contain mutations in either the BRAF or N-RAS oncogene and express markers of senescence, including p16. However, a nevus can contain 10s to 100s of thousand...
ORGANISM(S): Homo sapiens 
2013-08-01 | E-GEOD-46817 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of novel antigen presenting cells (APC) inducing pathogenic T helper cells of lupus
In lupus autoimmunity, pathogenic IgG autoantibodies that fix complement and bind FcGammaR on inflammatory cells, are produced with help from T helper (Th1 and Th17) cells specific for peptides from nucleosomes of apoptotic cells; and these Th cells also infiltrate vital organs (1-9). Macrophages (...
ORGANISM(S): Mus musculus 
2012-06-20 | E-GEOD-36284 | biostudies-arrayexpress
UnknownAsymmetric Hsp90 N domain SUMOylation recruits Aha1 and ATP-competitive inhibitors.
Not available
S-EPMC3964875 | biostudies-literature
UnknownMaternal pre-pregnancy BMI, offspring epigenome-wide DNA methylation, and childhood obesity: findings from the Boston Birth Cohort.
Not available
S-EPMC10463574 | biostudies-literature
UnknownUmbilical cord DNA methylation is associated with body mass index trajectories from birth to adolescence.
Not available
S-EPMC10141503 | biostudies-literature
TranscriptomicsExpression data from Uninfected and BRAF600V induced melanocytes
Melanocytes within benign human nevi are the paradigm for tumor suppressive senescent cells in a pre-malignant neoplasm. These cells typically contain mutations in either the BRAF or N-RAS oncogene and express markers of senescence, including p16. However, a nevus can contain 10s to 100s of thousand...
ORGANISM(S): Homo sapiens 
2013-08-01 | E-GEOD-46805 | biostudies-arrayexpress
UnknownBoston Birth Cohort profile: rationale and study design.
Not available
S-EPMC9844822 | biostudies-literature
TranscriptomicsGene expression comparison of E14.5 Foxd1 null and wild type kidneys
Forkhead transcription factors are essential for diverse processes in early embryonic development and organogenesis. Foxd1 is required during kidney development and its inactivation results in failure of nephron progenitor cell differentiation. Foxd1 is expressed in interstitial cells adjacent to ne...
ORGANISM(S): Mus musculus 
2013-11-14 | E-GEOD-52354 | biostudies-arrayexpress
Proteomicsc-Abl Dependent Tyrosine Phosphorylation of theCo-chaperone Aha1 Regulates Interaction with Hsp90
The ability of Heat Shock Protein 90 (Hsp90) to hydrolyze ATP is essential for its chaperone function. The co-chaperone Aha1 stimulates Hsp90 ATPase activity tailoring the chaperone function to specific “client” proteins. The intracellular signaling mechanisms directly regulating Aha1 association wi...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-28 | MSV000080713 | MassIVE
UnknownAre large clinical trials in orthopaedic trauma justified?
Not available
S-EPMC5909275 | biostudies-literature
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