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MetabolomicsAdaptive laboratory evolution of microbial co-cultures for improved metabolite secretion

Adaptive laboratory evolution has proven highly effective for obtaining microorganisms with enhanced capabilities. Yet, this method is inherently restricted to the traits that are positively linked to cell fitness, such as nutrient utilization. Here, we introduce coevolution of obligatory mutuali...

2021-07-02 | MTBLS2217 | MetaboLights
MetabolomicsAdaptive Evolution Reveals Mechanisms of Isobutanol Tolerance in Zymomonas mobilis

Isobutanol production has been demonstrated in E. coli and Z. mobilis using heterologous pathways, with titers reaching up to 60% of the theoretical yield under optimized conditions. However, these results often depend on impractical setups, such as continuous product extraction, oxygenation, or ...

2026-03-18 | MTBLS14081 | MetaboLights
MetabolomicsDNA nanomachines reveal an adaptive energy mode in confinement-induced amoeboid migration powered by polarized mitochondrial distribution

Energy metabolism is highly interdependent with adaptive cell migration in vivo. Mechanical confinement is a critical physical cue that induces switchable migration modes of the mesenchymal-to-amoeboid transition (MAT). However, the energy states in distinct migration modes, especially a...

2024-03-25 | MTBLS9657 | MetaboLights
MetabolomicsCardiac Resynchronization Therapy Induces Adaptive Metabolic Transitions in the Metabolomic Profile of Heart Failure
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ORGANISM(S): Homo sapiens 
ST000166 | MetabolomicsWorkbench
MetabolomicsA metabolomic study of Gomphrena agrestis in Brazilian Cerrado suggests drought-adaptive strategies on metabolism
Drought is the main factor that limits the distribution and productivity of plant species. In the Brazilian Cerrado, the vegetation is adapted to a seasonal climate with long- and short-term periods of drought. To analyze the metabolic strategies under such conditions, a metabolomic approach was use...
2021-10-06 | MTBLS613 | MetaboLights
MetabolomicsMetabolomics-Based Analysis of Adaptive Mechanism of Eleutheronema tetradactylum to Low-Temperature Stress

Temperature is a critical environmental factor influencing fish physiology. Eleutheronema tetradactylum is an economically important warm-water species, but its response to long-term cold stress remains unclear. In this study, we exposed juvenile fish to 18 °C for 7 and 14 days and investigated h...

2026-09-08 | MTBLS15459 | MetaboLights
MetabolomicsCXCL12 and MYC control energy metabolism to support adaptive responses after kidney injury
Kidney injury is a common complication of severe disease. Here, we report that injuries of the zebrafish embryonal kidney are rapidly repaired by a migratory response in 2-, but not in 1-day-old embryos. Gene expression profiles between these two developmental stages identify cxcl12a and myca as can...
2018-10-11 | MTBLS723 | MetaboLights
MetabolomicsPolyamines regulate adaptive antitumor immunity by functional specialization of regulatory T cells

In cancer, metabolic changes and uncontrolled tumor growth alter nutrient availability, impacting antitumor immune responses. Regulatory T (Treg) cells are a subset of T cells with immunosuppressive properties that has been found to additionally possess the ability to control tissue homeostasis a...

2025-07-24 | MTBLS12633 | MetaboLights
MetabolomicsStress-induced enrichment of Pseudomonas sp. stimulates the adaptive response of Auxenochlorella pyrenoidosa and antibiotic-resistant proliferation

The phycosphere is an important ecological niche for bacteria and antibiotic resistance genes (ARGs). However, whether and how the interaction between microalgae and bacteria changed, and its further effect on the transmission of ARGs under pollutant stress remains enigmatic. Here, Auxenochlorell...

2025-09-26 | MTBLS11371 | MetaboLights
MetabolomicsBiogeography shaped the metabolome of the genus Espeletia: a phytochemical perspective on an Andean adaptive radiation
The páramo ecosystem has the highest rate of diversification across plant lineages on earth, of which the genus Espeletia (Asteraceae) is a prime example. The current distribution and molecular phylogeny of Espeletia suggest the influence of Andean geography and past climatic fluctuations on the div...
2018-11-20 | MTBLS445 | MetaboLights
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