Sort   by:  
 Page size 
TranscriptomicsGenome-wide kinetics of DNA excision repair in relation to chromatin state and mutagenesis
We recently developed a high-resolution genome wide assay for mapping DNA excision repair named eXcision Repair-sequencing (XR-seq) (GEO accession: GSE67941) We have now used this assay to assay the effect of chromatin state on DNA repair. Here we report the results of a time-course of the repair o...
ORGANISM(S): Homo sapiens 
2016-03-15 | E-GEOD-76391 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of human global and transcription-coupled excision repair of UV damage at single-nucleotide resolution
We developed a method for genome-wide mapping of DNA excision repair named XR-seq (eXcision Repair-seq). Human nucleotide excision repair generates two incisions surrounding the site of damage, creating a ~30-mer. In XR-seq, this fragment is isolated and subjected to high-throughput sequencing. We u...
ORGANISM(S): Homo sapiens 
2015-04-19 | E-GEOD-67941 | biostudies-arrayexpress
GenomicsTranscriptional Repressor Gm129 Modulates the Circadian Gene Expression by Inhibiting CLOCK:BMAL1 Activity
The mammalian circadian clock is a molecular oscillator composed of a feedback loop that involves transcriptional activators CLOCK and BMAL1, and repressors Cryptochrome (CRY) and Period (PER). Here we show that a direct CLOCK-BMAL1 target gene, Gm129, is a novel regulator of the feedback loop. ChIP...
ORGANISM(S): Mus musculus 
2014-01-07 | E-GEOD-53828 | biostudies-arrayexpress
Sort   by:  
 Page size