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To understand the altered gene expression by D-galactose in galT cells, the cells were grown in the presence and absence of D-galactose and tiling array analysis was performed for transcriptome profiling. A galT defect causes the disease Galactosemia in human. This work helps us to study the human m...
ORGANISM(S): Escherichia coli 
E. coli RNA was hybridized to tiling arrays to study the pattern of gene expression across the chromosome. 1 sample for stationary phase and 1 for mid-exponential phase
ORGANISM(S): Escherichia coli str. K-12 substr. MG1655 
We used trimethylpsoralen intercalation to map supercoiling across the E. coli chromosome. We treated E. coli cells with trimethylpsoralen and exposed them to UV light. Psoralen enters cells, intercalates between DNA base pairs, and crosslinks the two strands of DNA at a rate proportional to the loc...
ORGANISM(S): Escherichia coli str. K-12 substr. MG1655 
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