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MetabolomicsMicrobial-derived 3-phenylpropionic acid orchestrates immune–progenitor cell crosstalk to promote beige adipogenesis and energy expenditure

Cold exposure induces beige adipogenesis in white adipose tissue (iWAT), enhancing thermogenesis and energy expenditure. While gut microbiota-derived metabolites are known to regulate host metabolism, their role in thermogenic adaptation remains poorly defined. Here, we identify Prevotella copri ...

2025-12-13 | MTBLS13503 | MetaboLights
TranscriptomicsExpression profiling of 3T3-L1 adipogenesis
3T3-L1 pre-adipocyte cells were grown to confluence and induced to differentiate in adipogeneic media. Two technical replicates from four time points relative to induction of adipogenesis (day 0)
ORGANISM(S): Mus musculus 
2010-09-30 | E-GEOD-20696 | biostudies-arrayexpress
TranscriptomicsLong non-coding RNAs regulate adipogenesis (Affymetrix)
Adipogenesis involves the regulation of hundreds of genes by several well-studied proteins, but the role of long, noncoding RNAs in this process has not been defined. We track the regulation of hundreds of lncRNAs during adipocyte differentiation, and find several that are essential for this proces...
ORGANISM(S): Mus musculus 
2013-02-15 | E-GEOD-29897 | biostudies-arrayexpress
TranscriptomicsLong non-coding RNAs regulate adipogenesis (Illumina RNA-Seq)
Adipogenesis involves the regulation of hundreds of genes by several well-studied proteins, but the role of long, noncoding RNAs in this process has not been defined. We track the regulation of hundreds of lncRNAs during adipocyte differentiation, and find several that are essential for this proces...
ORGANISM(S): Mus musculus 
2013-02-15 | E-GEOD-29898 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse 3T3-L1 fibroblasts differentiation during adipogenesis
3T3-L1 fibroblasts are a commonly used in vitro model for adipogenesis. When induced with hormones, they differentiate into mature fat cells. Here, microarrays were used to study 3T3-L1 adipose differentiation through time. Experiment Overall Design: 3T3-L1 fibroblasts were cultured in vitro and i...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-6794 | biostudies-arrayexpress
TranscriptomicsMicroRNA expression profiling of human adipose stromal cell (hASC) adipogenesis
Human abdominal adipose tissue was obtained with informed consent from a 33-year old Caucasian female (BMI = 32.96 Kg/m2) undergoing lipoaspiration. Adipose stromal cells (hASCs) were isolated and differentiated into adipocytes in vitro. Two technical replicates from 9 time points relative to induct...
ORGANISM(S): Homo sapiens 
2010-09-30 | E-GEOD-20699 | biostudies-arrayexpress
TranscriptomicsGene-chip studies of adipogenesis-regulated microRNAs in mouse primary adipocytes and human obesity
This SuperSeries is composed of the following subset Series: GSE27912: Gene-chip studies of adipogenesis-regulated microRNAs in mouse primary adipocytes and human obesity (Exiqon) GSE27949: Gene-chip studies of adipogenesis-regulated microRNAs in mouse primary adipocytes and human obesity (Affymetri...
ORGANISM(S): Homo sapiens 
2011-06-10 | E-GEOD-27951 | biostudies-arrayexpress
TranscriptomicsTranslational control in early adipogenesis
In obesity, adipose tissue expands by increasing the volume of existing adipocytes (hypertrophy), increasing the number of small adipocytes (hyperplasia) or both. Much is known about transcriptional control during adipogenesis, including early events. However, translational control plays a pivotal r...
ORGANISM(S): Mus musculus 
2012-03-28 | E-GEOD-29744 | biostudies-arrayexpress
TranscriptomicsGene-chip studies of adipogenesis-regulated microRNAs in mouse primary adipocytes and human obesity (Exiqon)
Adipose tissue abundance relies partly on the factors that regulate adipogenesis, i.e. proliferation and differentiation of adipocytes. While the transcriptional program that initiates adipogenesis is well-known, the importance of microRNAs in adipogenesis is less well studied. We thus set out to in...
ORGANISM(S): Mus musculus 
2011-05-31 | E-GEOD-27912 | biostudies-arrayexpress
TranscriptomicsGene-chip studies of adipogenesis-regulated microRNAs in mouse primary adipocytes and human obesity (Affymetrix)
Adipose tissue abundance relies partly on the factors that regulate adipogenesis, i.e. proliferation and differentiation of adipocytes. While the transcriptional program that initiates adipogenesis is well-known, the importance of microRNAs in adipogenesis is less well studied. We thus set out to in...
ORGANISM(S): Homo sapiens 
2011-05-31 | E-GEOD-27949 | biostudies-arrayexpress
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